Cochrane · systematic review · CD009012
Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis
Eshun‐Wilson, I, Okwen, MP, Richardson, M, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
4
current version
GRADE rated
4
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsEarly ART compared to delayed ART initiation in HIV‐positive people with cryptococcal meningitis
Population: HIV‐positive people with cryptococcal meningitis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
All‐cause mortality at 6 to 12 months Early ART vs delayed ART initiation | RR 1.42 [1.02, 1.97] | 4 studies · 294 participants | Low Downgraded: risk of bias, imprecision, inconsistency |
Cryptococcal meningitis relapse Early ART vs delayed ART initiation | RR 0.27 [0.07, 1.04] | 2 studies · 205 participants | Low Downgraded: imprecision |
Cryptococcal IRIS Early ART vs delayed ART initiation | RR 3.56 [0.51, 25.02] | 2 studies · 205 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
HIV virological suppression at 6 months (viral load < 400 copies/mL) Early ART vs delayed ART initiation | RR 0.93 [0.72, 1.22] | 2 studies · 205 participants | Very low Downgraded: risk of bias, imprecision |