Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

289 questions · 295 findings · 34 reviews

No studies found 37 · 12.5%GRADE not reported 10 · 3.4%Very low 103 · 34.9%Low 66 · 22.4%Moderate 65 · 22%High 14 · 4.7%

Antibiotics vs other antibiotics

Laboratory‐confirmed leptospirosis · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis confirmed by laboratory diagnosis compared with other antibiotics (very low certainty).

2 findings from 1 review

Antibiotics vs other antibiotics

Non‐serious adverse events · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with other antibiotics (very low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo

Preterm prelabour rupture of membranes · women in the second or third trimester of pregnancy before labour and delivery

Prophylactic antibiotics showed no clear difference in preterm prelabour rupture of membranes compared with placebo (low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo

Puerperal sepsis/postpartum endometritis · women in the second or third trimester of pregnancy before labour and delivery

Prophylactic antibiotics probably leads to lower puerperal sepsis/postpartum endometritis compared with placebo (moderate certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Respiratory infections · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis probably leads to lower respiratory tract infections compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Dropouts due to adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in dropouts due to adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Gastrointestinal adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in gastrointestinal adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review

Topical plus systemic prophylaxis vs placebo or no treatment

Allergic adverse events · adults receiving mechanical ventilation for at least 48 hours

Topical plus systemic prophylaxis showed no clear difference in allergic adverse events compared with placebo or no treatment (low certainty).

1 finding from 1 review