Findings

What do systematic reviews say?

3,372 questions · 3,874 findings · 666 reviews

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No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

'As needed' administration (e.g. based on pain scales) vs monthly injections

QoL · people with neovascular age‐related macular degeneration

1 finding from 1 review

Treatment regimens for administration of anti‐vascular endothelial growth factor agents for neovascular age‐related… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 498 participants
Low

Extended‐fixed vs monthly injections

Change in BCVA at 1 year (ETDRS letters score, the higher the score the better) · people with neovascular age‐related macular degeneration

1 finding from 1 review

Treatment regimens for administration of anti‐vascular endothelial growth factor agents for neovascular age‐related… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1439 participants
Moderate

rHuEPO with iron vs control treatment with or without iron

Subgroup Hb concentration immediately prior to surgery (g/dL) rHuEPO high (500 to 600 IU/kg BW) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

1 finding from 1 review

Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing… 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 852 participants
Low

Resilience interventions vs control condition

Resilience Measured by: investigators measured resilience using different instruments; higher scores mean higher resilience Timing of outcome assessment: post‐intervention · healthcare workers

1 finding from 1 review

Psychological interventions to foster resilience in healthcare professionals 2020 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 690 participants
Very low

Resilience interventions vs control condition

Quality of life/Mental health outcome · healthcare workers

1 finding from 1 review

Psychological interventions to foster resilience in healthcare professionals 2020 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1494 participants
Very low

Implementation interventions vs no intervention

HRQoL at 6 or 12 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: HRQoL (EQ‐5D: –0.59 to 1, higher score… compared with no intervention (moderate certainty).

1 finding from 1 review

Implementation interventions to promote the uptake of evidence‐based practices in stroke rehabilitation 2020 · Cochrane Headline outcomes only
MD 0.01
2 studies · 1242 participants
Moderate

Implementation interventions vs no intervention

Patient health status: ADL (Barthel Index, 0–20, higher score = better) at up to 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: ADL (Barthel Index, 0–20, higher score =… compared with no intervention (moderate certainty).

1 finding from 1 review

Implementation interventions to promote the uptake of evidence‐based practices in stroke rehabilitation 2020 · Cochrane Headline outcomes only
MD 0.29
2 studies · 1272 participants
Moderate

Implementation interventions vs no intervention

Patient health status: psychological well‐being (GHQ‐12, 0–36, higher score = worse) at up to 6 months · healthcare professionals providing stroke rehabilitation

Implementation interventions showed no clear difference in patient health status: psychological well‐being (GHQ‐12, 0–36,… compared with no intervention (low certainty).

1 finding from 1 review

Implementation interventions to promote the uptake of evidence‐based practices in stroke rehabilitation 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1273 participants
Low

Benzodiazepines (lorazepam) vs haloperidol

Severity of delirium · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Benzodiazepines (lorazepam) vs haloperidol

Any adverse event ESRS, higher = worse · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 17 participants
Very low

Benzodiazepines (lorazepam) vs placebo

Severity of delirium · end‐of‐life patients with advanced cancer and an episode of agitated delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Benzodiazepines (lorazepam) vs chlorpromazine

Severity of delirium · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Benzodiazepines (lorazepam) vs chlorpromazine

Any adverse event ESRS, higher = worse · adult AIDS patients with delirium

1 finding from 1 review

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Very low

Wavefront‐optimized procedures vs wavefront‐guided procedures

Mean higher‐order aberrations (HOAs) post‐treatment, measured by machine with wavefront sensor ‐ 12 months · Adults with refractive errors

1 finding from 1 review

Wavefront excimer laser refractive surgery for adults with refractive errors 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 622 participants
Low

Wavefront‐guided LASIK vs wavefront‐guided PRK

Mean higher‐order aberrations (HOAs) post‐treatment, measured by machine with wavefront sensor ‐ 12 months · Adults with refractive errors

1 finding from 1 review

Wavefront excimer laser refractive surgery for adults with refractive errors 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

Wavefront procedures vs conventional procedures

Proportion of eyes that had lost 1 or more lines of best spectacle‐corrected visual acuity (BSCVA) posttreatment‐procedure LASIK; Mean higher‐order aberrations (HOAs) post‐treatment, measured by machine with wavefront sensor; proportion of eyes wi... · Adults with refractive errors

The review found no eligible studies for this question.

1 finding from 1 review

Wavefront excimer laser refractive surgery for adults with refractive errors 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hospital‐based specialist palliative care vs usual care

Health‐related quality of life (HRQoL) · adults with advanced illness and their unpaid caregivers/families

1 finding from 1 review

The effectiveness and cost‐effectiveness of hospital‐based specialist palliative care for adults with advanced illness… 2020 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 1344 participants
Low

Hospital‐based specialist palliative care vs usual care

Patient satisfaction with careiii, SD units(higher scores indicate better patient satisfaction) · adults with advanced illness and their unpaid caregivers/families

1 finding from 1 review

The effectiveness and cost‐effectiveness of hospital‐based specialist palliative care for adults with advanced illness… 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 337 participants
Low

Intervention not reported

Patient harms associated with patient and family involvement in escalation of care (5a) Multiple Affect Adjective Checklist total score for state anxiety (range 0‐21). Higher scores signify higher anxiety; a score of ≥ 11 indicates clinically sign... · Adults (and/or family members) with potential for acute life‐threatening illness

1 finding from 1 review

Interventions to increase patient and family involvement in escalation of care for acute life‐threatening illness in… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2597 participants
Moderate

Knee replacement with tourniquet vs knee replacement without tourniquet

Pain on movement at 24 hours Visual analogue scale Scale from zero to 10

1 finding from 1 review

Tourniquet use for knee replacement surgery 2020 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 577 participants
Moderate