Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Standard treatment plus systemic corticosteroids vs usual care

Severity of pain on day 3 · patients age 10 years and older with periorbital or orbital cellulitis

It is very uncertain whether standard treatment plus systemic corticosteroids changes severity of pain on day 3 compared with standard treatment alone (very low certainty).

1 finding from 1 review

Hydroxychloroquine (HCQ) vs placebo or usual care

Negative PCR for SARS‐CoV‐2 on respiratory samples at day 14 from enrolmentd · adults with mild to severe COVID‐19

Hydroxychloroquine (HCQ) showed no clear difference in negative PCR for SARS‐CoV‐2 on respiratory samples at day 14 from… compared with standard care or placebo (low certainty).

1 finding from 1 review

Hydroxychloroquine (HCQ) vs placebo

Development of confirmed COVID‐19 at 14 days from enrolment · people who have been exposed to SARS‐CoV‐2

It is very uncertain whether hydroxychloroquine (HCQ) changes development of confirmed COVID‐19 at 14 days from enrolment compared with placebo (very low certainty).

1 finding from 1 review