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Evidence found and GRADE certainty

1,378 questions · 2,146 findings · 145 reviews

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No studies found 167 · 7.8%GRADE not reported 1,674 · 78%Very low 148 · 6.9%Low 113 · 5.3%Moderate 40 · 1.9%High 4 · 0.2%

Fluoride toothpaste vs Placebo (non-fluoride) toothpaste or fluoride toothpaste of a different concentration

Adverse effects of toothpaste · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Toothbrushing alone

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes plaque compared with toothbrushing alone (very low certainty).

1 finding from 1 review

Antimicrobial photodynamic therapy (PDT) vs No photodynamic therapy (untreated negative control)

Microbial reduction (viable count, log CFU/mL) · Cariogenic bacteria (mainly Streptococcus mutans reference strains) and oral biofilms in vitro

In in vitro studies, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -2.64, 95% CI -4.50 to -0.79; 2 studies; I2=0%); certainty was not graded.

1 finding from 1 review

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Decayed, missing, filled surfaces (DMFS) · pregnant women

Women who experienced preterm birth did not have a significantly different DMFS than those who did not (mean difference -0.15, 95% CI -3.40 to 3.09; 3 studies; I2=89%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD -0.15 [-3.40, 3.09]
    3 studies · 2594 participants
    GRADE not reported

Women who experienced preterm birth vs Women who did not experience preterm birth (term)

Dental caries · pregnant women

Women who experienced preterm birth did not have significantly higher DMFT than those who did not (mean difference 1.56, 95% CI -0.28 to 3.41; 5 studies; I2=92%); certainty of evidence not graded.

1 finding from 1 review
  • Dental caries and preterm birth: a systematic review and meta-analysis. 2018 All outcomes
    Pregnant women assessed around delivery in observational studies across multiple countries (Mexico, Malawi, India, France, Jordan, Finland, Tanzania); mostly retrospective cohort and case-control designs
    MD 1.56 [-0.28, 3.41]
    5 studies · 2963 participants
    GRADE not reported

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Marginal deterioration of the restoration and fracture of the remaining tooth tissue · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…
1 finding from 1 review

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Restoration survival · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…
1 finding from 1 review

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Economic data: direct costs of materials and any reported associated indirect costs · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Signs of acute toxicity during gel application (nausea, gagging, vomiting) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

It is very uncertain whether fluoride mouthrinse (any fluoride agent, concentration, volume,… changes unacceptability of treatment as measured by leaving study early… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Adverse effects · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…

The review found no eligible studies for this question.

1 finding from 1 review