Question · asked by 1 review
Fluoride toothpaste vs Placebo (non-fluoride) toothpaste or fluoride toothpaste of a different concentration: Adverse effects of toothpaste
- Population
- Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
- Intervention
- Fluoride toothpaste
- Comparison
- Placebo (non-fluoride) toothpaste or fluoride toothpaste of a different concentration
- Outcome
- Adverse effects of toothpaste
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Fluoride toothpaste (any concentration; pooled across comparisons) vs Lower-concentration or non-fluoride toothpaste (pooled across comparisons) Adverse effects of toothpaste · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start) · Closest to 36 months Fluoride toothpastes of different concentrations for preventing dental caries (2019) · Cochrane All outcomes | 16 studies assessed possible side effects, principally oral (soft tissue) pathologies and tooth staining. 6 studies reported no untoward events; 6 reported greater staining in the stannous fluoride group; 1 reported no… | 16 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes | 2018-08 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.