Non-Cochrane · aetiology · PM29500202
Dental caries and preterm birth: a systematic review and meta-analysis.
Wagle Madhu, D'Antonio Francesco, Reierth Eirik, et al. · BMJ open · 2018 · PubMed · doi:10.1136/bmjopen-2017-018556
Full textEvery question was extracted from the full text, figures and supplements by two independent LLM extractors, disagreements adjudicated. Rows cite where in the review the value comes from.
Questions
5
current version
GRADE rated
0
No studies
0
Included studies
9
linked below
No studies 0 · 0%Ungraded 5 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Review question
| Element | Planned (methods) | Found (results) |
|---|---|---|
| Population | Pregnant women | Pregnant women across 9 observational studies (4826 pregnancies) |
| Intervention | Dental caries during pregnancy (exposure) | Dental caries during pregnancy |
| Comparison | Pregnant women without dental caries | No dental caries (for PTB outcome); term birth (for DMFT/DMFS outcomes) |
| Outcomes | Primary: preterm birth (birth <37 weeks of gestation). Secondary: DMFT and DMFS indices (caries severity) compared between women with vs without PTB | Preterm birth: OR 1.16 (95% CI 0.90 to 1.49; 5 studies; I2=35%). DMFT (PTB vs non-PTB): MD 1.56 (95% CI -0.28 to 3.41; 5 studies; I2=92%). DMFS (PTB vs non-PTB): MD -0.15 (95% CI -3.40 to 3.09; 3 studies; I2=89%) |
| Study designs | Observational cohort and case-control studies; case reports, conference abstracts and case series with <3 cases excluded | 9 observational studies (n=7 retrospective, n=2 prospective; cohort and case-control), 4826 pregnancies |
| Timing | Not specified | Dental examination timing varied by study, from the first trimester of pregnancy to within ~8 weeks post partum |
Search date: November 2015; repeated December 2016. Databases: Ovid MEDLINE (incl. In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid MEDLINE and Ovid OLDMEDLINE), Embase Classic + EMBASE (Ovid), Web of Science (Thomson Reuters), Cochrane Library (Wiley), CINAHL Plus (EBSCOhost); plus hand-searching of reference lists of relevant articles…
Questions and results
Dental caries during pregnancy vs Pregnant women without dental caries
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Preterm birth stratified by clinical type (spontaneous vs iatrogenic vs term) By type of PTB (spontaneous vs iatrogenic) The planned subanalysis by type of preterm birth (spontaneous vs iatrogenic vs term) could not be performed because of the small number of cases and lack of information in the original studies. Source: Methods (planned categorisation by type of PTB); Results (Synthesis of the results - 'not possible to perform any subanalysis according to… · same question in other reviews | no estimate extracted | 0 studies | Ungraded |
Preterm birth stratified by gestational age at birth (moderate-to-late 32 to <37, very 28 to <32, extremely <28 weeks) By gestational age at birth The planned subanalysis of preterm birth by gestational age at birth (moderate-to-late, very, extremely preterm) could not be performed because of the small number of cases and lack of stratified data in the original studies. Source: Methods (Study selection, data collection and data items - planned stratification by gestational age); Results (Synthesis of the results -… · same question in other reviews | no estimate extracted | 0 studies | Ungraded |
Preterm birth (<37 weeks of gestation) Pregnant women with dental caries did not have a significantly increased risk of preterm birth (pooled OR 1.16, 95% CI 0.90 to 1.49; 5 studies; I2=35%); certainty of evidence not graded. Source: Results (Synthesis of the results); Table 3; Figure 2; Abstract · same question in other reviews | OR 1.16 [0.90, 1.49] | 5 studies · 4246 participants | Ungraded |
Women who experienced preterm birth vs Women who did not experience preterm birth (term)
Population: Pregnant women
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
DMFT index (decayed, missing and filled teeth) Women who experienced preterm birth did not have significantly higher DMFT than those who did not (mean difference 1.56, 95% CI -0.28 to 3.41; 5 studies; I2=92%); certainty of evidence not graded. Source: Results (Synthesis of the results); Table 3; Figure 3a; Abstract · same question in other reviews | MD 1.56 [-0.28, 3.41] | 5 studies · 2963 participants | Ungraded |
DMFS index (decayed, missing and filled surfaces) Women who experienced preterm birth did not have a significantly different DMFS than those who did not (mean difference -0.15, 95% CI -3.40 to 3.09; 3 studies; I2=89%); certainty of evidence not graded. Source: Results (Synthesis of the results); Table 3; Figure 3b; Abstract · same question in other reviews | MD -0.15 [-3.40, 3.09] | 3 studies · 2594 participants | Ungraded |
Included primary studies 9
Open as a trial list| Study | Also included by | Outcomes it informs here | Trial PICO | Results |
|---|---|---|---|---|
| Acharya et al., 2013 Dental neglect and adverse birth outcomes: a validation and observational study DOI:10.1111/idh.12001 | this review only | Preterm birth (<37 weeks of gestation) | not extracted yet | not extracted yet |
| Durand et al., 2009 A pilot study of the association between cariogenic oral bacteria and preterm birth* DOI:10.1111/j.1601-0825.2009.01559.x | this review only | DMFS index (decayed, missing and filled surfaces) | not extracted yet | not extracted yet |
| Harjunmaa et al., 2015 Association between maternal dental periapical infections and pregnancy outcomes: results from a cross‐sectional study in Malawi DOI:10.1111/tmi.12579 | this review only | Preterm birth (<37 weeks of gestation) | not extracted yet | not extracted yet |
| Heimonen et al., 2008 Postpartum oral health parameters in women with preterm birth DOI:10.1080/00016350802307620 | this review only | Preterm birth (<37 weeks of gestation) | not extracted yet | not extracted yet |
| Martinez-Martinez et al., 2016 Association between periodontitis, periodontopathogens and preterm birth: is it real? DOI:10.1007/s00404-015-3945-1 | this review only | DMFT index (decayed, missing and filled teeth) | not extracted yet | not extracted yet |
| Meurman et al., 2006 Oral health in women with pregnancy and delivery complications DOI:10.1007/s00784-006-0037-4 | this review only | DMFT index (decayed, missing and filled teeth) | not extracted yet | not extracted yet |
| Mumghamba and Manji, 2007 Maternal oral health status and preterm low birth weight at Muhimbili National Hospital, Tanzania: a case-control study. PMID:17594498 | this review only | Preterm birth (<37 weeks of gestation) | not extracted yet | not extracted yet |
| Ryalat et al., 2011 Effect of Oral Diseases on Mothers Giving Birth to Preterm Infants DOI:10.1159/000329887 | this review only | DMFT index (decayed, missing and filled teeth) | not extracted yet | not extracted yet |
| Vergnes et al., 2011 Maternal dental caries and pre-term birth: Results from the EPIPAP study DOI:10.3109/00016357.2011.563242 | this review only | Preterm birth (<37 weeks of gestation) | not extracted yet | not extracted yet |