Antimicrobial photodynamic therapy (PDT) vs No photodynamic therapy (untreated negative control): Microbial reduction (viable count, log CFU/mL)
In in vitro studies, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -2.64, 95% CI -4.50 to -0.79; 2 studies; I2=0%); certainty was not graded.
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Antimicrobial photodynamic therapy (PDT) vs No photodynamic therapy (untreated negative control) Microbial reduction (viable count, log CFU/mL) · Cariogenic microorganisms in vitro (Streptococcus mutans and multispecies cariogenic biofilms) · In vitro (laboratory), In vitro studies In in vitro studies, photodynamic therapy significantly reduced cariogenic microbial counts versus untreated control (SMD -2.64, 95% CI -4.50 to -0.79; 2 studies; I2=0%); certainty was not graded. Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and… (2019) All outcomes | SMD -2.64 [-4.50, -0.79] | 2 studies · 14 participants | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis. 2019 All outcomes | December 1989 to March 2019 | 65 | Critically Low / Critically Low |
Studies behind the findings
The primary studies the full-text reviews tie to this outcome. Reviews with headline outcomes only do not list them here.
- Could chlorhexidine be an adequate positive control for antimicrobial photodynamic therapy in- in vitro studies? · 2019 · included by 1 of these review
- Could chlorhexidine be an adequate positive control for antimicrobial photodynamic therapy in- in vitro studies? · 2019 · included by 1 of these review
- Influence of pre-irradiation time employed in antimicrobial photodynamic therapy with diode laser. · 2018 · included by 1 of these review
- Influence of pre-irradiation time employed in antimicrobial photodynamic therapy with diode laser · 2017 · included by 1 of these review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.