Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
Under remineralizing conditions, nHA produced significantly more remineralization than the negative control (MD 350, 95% CI 179 to 521; very low certainty).
2 findings from 1 review
Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro)
SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD 0.26 MPa, 95% CI -0.30 to 0.82; ungraded).
1 finding from 1 review
Mucosal (oral) hyperpigmentation · Children or adolescents
CLWH on ART had significantly higher prevalence of mucosal hyperpigmentation than healthy controls (pooled OR 20.35, 95% CI 3.86 to 107.39); the authors described the certainty as low.
1 finding from 1 review
Caries experience · Children (mean age newborn to ~5.2 years) and their parents/carers
Oral-health-education-only interventions showed at most a marginal effect on tooth-level caries (dmft SMD -0.11, 95% CI -0.21 to -0.00; 2 studies; not GRADE-rated).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)
Prior SDF without a rinsing step significantly reduces adhesive bond strength to sound dentin (MD 17.52 MPa favoring untreated dentin, 95% CI 5.81 to 29.22; ungraded).
1 finding from 1 review
Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)
Gender is not associated with caries development in permanent teeth (OR 0.86, 95% CI 0.71 to 1.02; low certainty).
1 finding from 1 review
Caries experience · European adolescents aged 12 years
Pooled caries experience was 5.62 (I² = 99.9%).
1 finding from 1 review
Other orofacial opportunistic infections (linear gingival erythema, hairy leukoplakia, angular cheilitis, oral ulcers) · Children and adolescents living with HIV on ART/HAART
ART/HAART duration had minimal influence on the prevalence of orofacial opportunistic infections other than candidiasis (no significant differences).
1 finding from 1 review
Oral Health Status of Children and Adolescents Living with HIV Undergoing Antiretroviral Therapy: A Systematic Review… 2022 All outcomesCross-sectional (case-control; single time point) · HIV pediatric/ART clinics, AIDS centers, and hospitals in Brazil, India, Saudi Arabia, and West Africa (Cote d'Ivoire, Mali, Senegal) · ART/HAART duration <3 years vs >=3 years
Except for candidiasis, no significant differences in the prevalence of opportunistic infection manifestations (linear gingival erythema, hairy leukoplakia, angular cheilitis, oral ulcers) between ART duration <3 years…
2 studies
GRADE not reported
Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Non-responsive complementary feeding showed no significant association with overweight/obesity across observational studies (very low certainty).
1 finding from 1 review
Oral health-related quality of life · Children with dental caries
ART and placebo did not differ for oral health-related quality of life, based on an indirect network estimate with no direct trials (MD -0.01, 95% CI -0.40 to 0.38; ungraded).
3 findings from 1 review
Ulcerative stomatitis · Children or adolescents
One study found significantly higher ulcerative stomatitis among CLWH on ART (OR 28.59, 95% CI 1.67 to 490.32), though the estimate is very imprecise.
1 finding from 1 review
Plaque · Adults and children (predominantly adults; one study in children), with natural dentition
Xylitol sugar-free gum significantly reduced plaque quantity versus no-gum/control (SMD -0.743, 95% CI -1.148 to -0.338), with high heterogeneity (I2 = 86.0%; ungraded).
1 finding from 1 review
Enamel caries proportion · European adolescents aged 17 years
Pooled enamel caries proportion was 0.58.
1 finding from 1 review
Secondary caries · Patients with permanent dentition in need of restorations (all cavity types: Black's Class I, II, V, and non-carious cervical lesions)
Pooled across follow-up periods, ion-releasing (GIC) and resin composite restorations show no significant difference in secondary caries (RD -0.00, 95% CI -0.01 to 0.00; not separately GRADE-rated).
6 findings from 1 review
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomesOverall (1 year, 18 months-2 years, and 3 years pooled) · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.00]
12 studies · 3085 participants
GRADE not reported
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes18 months-2 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
8 studies · 1087 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · University, private practice, primary school, and multicenter settings · All types of cavities
RD -0.00 [-0.01, 0.01]
12 studies · 1677 participants
Low
Show 3 more findings
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes3 years · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD 0.00 [-0.02, 0.02]
3 studies · 321 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes1 year · Permanent dentition; university (majority), school, and private-practice settings across multiple countries (Turkey, Brazil, Sweden, India, Vietnam, Belgium, Germany, etc.)
RD -0.00 [-0.01, 0.01]
12 studies · 1677 participants
Low
Secondary caries and marginal adaptation of ion-releasing versus resin composite restorations: a systematic review and… 2022 All outcomes18 months to 2 years · University, private practice, primary school, and multicenter settings · All types of cavities
RD -0.00 [-0.01, 0.01]
8 studies · 1087 participants
Low
Plaque index (PI) / oral hygiene · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs)
School-based interventions may reduce dental plaque scores (SMD -0.32, favouring intervention), but the certainty of evidence is very low.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R43 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R43 was significantly associated with ECC in the TWAS (p = 8.78e-8); genetic association, ungraded.
1 finding from 1 review
Differential microbial abundance / taxa predictive of caries · Individuals providing oral (saliva/supragingival plaque) 16S rRNA microbiome samples; 2016 samples from 19 studies (mixed children and…
A group of genera/species (notably Selenomonas, Aggregatibacter, Actinomyces, Treponema) was predictive of caries, whereas Streptococcus was not (ungraded).
1 finding from 1 review
Meta-analysis of caries microbiome studies can improve upon disease prediction outcomes. 2022 All outcomesOral cavity microbiome (saliva and supragingival plaque samples); pooled across 19 international studies
Mean-decrease-accuracy discriminating taxa: Capnocytophaga HMT-338, Lactobacillus panis, Treponema HMT-230, Bifidobacterium longum, Delftia acidovorans, Staphylococcus schleiferi; higher log2FC in caries: Selenomonas HMT-146, Aggregatibacter actinomycetemcomitans, Actinomyces HMT-896, Treponema HMT-257; Streptococcus not predictive
19 studies · 2016 participants
GRADE not reported
Weight gain · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries
Narratively, restrictive NRCF style tended to favor excess weight and coercive/pressuring style tended to favor lower weight (3 of 5 studies each; ungraded).
1 finding from 1 review
Dental caries prevalence · Children aged 12 years (plus or minus one year) in Africa
The pooled dental-caries prevalence was 0.3657 (95% CI 0.3065 to 0.4250); GRADE was not reported.
2 findings from 1 review
Prevalence 0.3657 [0.3065, 0.4250]
Studies not reported
GRADE not reported
Prevalence 0.356 [0.294, 0.417]
Studies not reported
GRADE not reported
Early childhood caries (ECC) - association with genetically predicted expression of SMIM10L1 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of SMIM10L1 was significantly associated with ECC in the TWAS (p = 1.70e-7); genetic association, ungraded.
1 finding from 1 review