What do systematic reviews say?

Lifestyle interventions vs minimal treatment

• Lifestyle changes in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 434 participants
  Low

Lifestyle interventions vs minimal treatment

• Lifestyle changes in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 121 participants
  Low

Amifostine vs no otoprotective intervention

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intra‐arterial… compared with no otoprotective intervention (low certainty).

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  RR 1.29 [0.94, 1.77]
  1 study · 28 participants
  Low

Amifostine vs no otoprotective intervention

Amifostine showed no clear difference in ototoxicity according to NCICTCv2 criteria with intravenous platinum… compared with no otoprotective intervention (low certainty).

• Medical interventions for the prevention of platinum‐induced hearing loss in children with cancer 2019 · Cochrane Headline outcomes only
  RR 1.04 [0.76, 1.44]
  1 study · 36 participants
  Low

Intervention not reported

• Enzyme replacement therapy with laronidase (Aldurazyme®) for treating mucopolysaccharidosis type I 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 45 participants
  Low

Surgical vs conservative interventions

It is very uncertain whether surgical changes cosmetic problemi compared with conservative interventions (very low certainty).

• Surgical versus conservative interventions for treating fractures of the middle third of the clavicle 2019 · Cochrane Headline outcomes only
  RR 0.55 [0.31, 0.98]
  11 studies · 1130 participants
  Very low

Human albumin infusion plus furosemide vs glucose

• Human albumin infusion for treating oedema in people with nephrotic syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 26 participants
  Very low

Exercise vs control group

• Exercise training undertaken by people within 12 months of lung resection for non‐small cell lung cancer 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 182 participants
  High

Chest physiotherapy vs no chest physiotherapy

Chest physiotherapy showed no clear difference in time to clinical resolution (all parameters) ( compared with no chest physiotherapy (low certainty).

• Chest physiotherapy for pneumonia in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 559 participants
  Low

Dialectic behaviour therapy with case management vs a health promotion scheme

It is very uncertain whether dialectic behaviour therapy with case management changes number not using methamphetamine at 6 months compared with a health promotion scheme (very low certainty).

• Interventions for female drug‐using offenders 2019 · Cochrane Headline outcomes only
  RR 1.02 [0.87, 1.2]
  1 study · 116 participants
  Very low

IPV‐OPV vs IPV

• Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 363 participants
  Moderate

IPV‐OPV vs OPV

• Sequential inactivated (IPV) and live oral (OPV) poliovirus vaccines for preventing poliomyelitis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 795 participants
  Low

Intervention not reported

• Food fortification with multiple micronutrients: impact on health outcomes in general population 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 2889 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Food fortification with multiple micronutrients: impact on health outcomes in general population 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Altered fraction schedules vs Conventional (standard) fractionation radiotherapy

Altered fraction schedules showed no clear difference in metastasis‐free survival compared with conventional fractionation (low certainty).

• Hypofractionation for clinically localized prostate cancer 2019 · Cochrane Headline outcomes only
  HR 1.07 [0.65, 1.76]
  5 studies · 4985 participants
  Low

Fluoxetine vs placebo

• Fluoxetine for adults who are overweight or obese 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 97 participants
  Very low

Equivalent schedules of intradermal fractional‐dose inactivated poliovirus vaccine vs intramuscular inactivated poliovirus vaccine

• Equivalent schedules of intradermal fractional dose versus intramuscular full dose of inactivated polio vaccine for… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 4887 participants
  Very low

Primary (complete) wound closure vs no closure

Primary closure showed no clear difference in cosmesis using validated cosmetic outcome score at 4 weeks Scale:… compared with no closure (moderate certainty).

• ​Primary closure versus delayed or no closure for traumatic wounds due to mammalian bite 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 182 participants
  Moderate

Primary (complete) wound closure vs delayed closure

The review found no eligible studies for this question.

• ​Primary closure versus delayed or no closure for traumatic wounds due to mammalian bite 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Sternocleidomastoid muscle flap vs no flap

Sternocleidomastoid muscle flap showed no clear difference in other complications As measured by: clinical methods and subjective… compared with no flap (low certainty).

• Graft interposition for preventing Frey's syndrome in patients undergoing parotidectomy 2019 · Cochrane Headline outcomes only
  RR 2.18 [0.09, 50.16]
  1 study · 36 participants
  Low