Poor oral health-related quality of life (OHRQoL) · Adolescents (10-19 years)
Malocclusions probably have a negative effect on OHRQoL in adolescents, after adjustment for confounders (moderate certainty).
1 finding from 1 review
Impaired OHRQoL, qualitative synthesis: relative effect not estimable across the 13 studies (13,864 participants); moderate quality of evidence (GRADE).
13 studies · 13864 participants
Moderate
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
Over 2 or more years in deciduous teeth, amalgam probably had a higher risk of secondary caries than RMGIC (RR 2.46, 95% CI 1.42-4.27; moderate certainty).
1 finding from 1 review
MMP-20 expression · Human ex vivo carious dentin (head/neck radiotherapy)
MMP-20 shows no difference between irradiated and non-irradiated carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference about the MMP-20 expression in irradiated vs. non-irradiated carious dentin, but the evidence is very uncertain (Gomes-Silva et al., 2017b).
1 study · 36 participants
Very low
Intervention not reported
New active carious lesions (permanent first molars)
1 finding from 1 review
Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced several plaque-related indices, but certainty is very low.
1 finding from 1 review
Intervention not reported
Pulp necrosis
1 finding from 1 review
Proportion 3.27
1 study
GRADE not reported
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
Over 2 or more years in deciduous teeth, the difference in secondary caries between giomer and RMGIC is uncertain (RR 1.66, 95% CI 0.49-5.61; low certainty).
1 finding from 1 review
Shear bond strength (SBS) of metallic orthodontic brackets · Extracted permanent human teeth (enamel); sound or demineralized
CPP-ACP enamel pre-treatment before bonding did not significantly affect the shear bond strength of metallic orthodontic brackets (MD 1.163 MPa, 95% CI -0.321 to 2.648; ungraded).
1 finding from 1 review
Salivary flow rate (unstimulated) · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
In elderly and medically compromised people with xerostomia, chewing sugar-free gum daily for two or more weeks produces a small but statistically significant increase in unstimulated whole salivary flow rate versus no gum (SMD 0.44, 95% CI 0.22 to 0.66); certainty of evidence was not formally graded.
1 finding from 1 review
New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time 38% SDF gave a 57% prevented fraction for caries in children's permanent first molars (single study; ungraded).
1 finding from 1 review
new root-surface carious lesions or restorations · community-dwelling older adults with root caries
SDF had a 28% preventative fraction at 24 months; no pooled estimate or GRADE rating was reported.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
MTA and Biodentine performed comparably for clinical and radiographic success (5 RCTs, not pooled; ungraded).
1 finding from 1 review
Intervention not reported
Caries arrest rate in permanent posterior teeth
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACP did not differ significantly from control (SMD -0.18, 95% CI -0.49 to 0.14); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Risk of malnutrition (younger children, 6 months to 6 years) · Children aged ≤6 years (early childhood)
One Nepalese cross-sectional study found no significant association between severe ECC and malnutrition risk in children under 6 (mean difference 0.13, p=0.609); ungraded.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth
MTA increases clinical and radiographic success versus CH in mature teeth (moderate certainty).
1 finding from 1 review
Cathepsin B (CT-B) presence/activity · Human coronal carious dentin and sound dentin
Cathepsin B may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
Dry mouth (xerostomia) · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
Gum chewing was linked with improved self-reported xerostomia / dry mouth in most studies (12 of 17 positive, 5 no effect); heterogeneous instruments precluded meta-analysis.
1 finding from 1 review
The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a… 2023 All outcomesVarious (single session to 3 months) · Haemodialysis units, elderly / geriatric care, cancer and palliative care, and xerostomia / hyposalivation clinics (studies from multiple countries)
Narrative vote-count: of 17 studies measuring self-reported xerostomia / dry mouth, 12 found a positive effect of gum chewing [18,19,21,23,24,25,26,27,30,31,38,40] and 5 detected no effect [17,29,33,34,37]. No study…
17 studies
GRADE not reported
Total bacteria (colony count) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash may reduce total bacteria colony counts versus blank control in the short term, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
CPP-ACFP versus control gave SMD -0.42 (95% CI -0.84 to 0.00); the review classed CPP-ACFP as statistically significant versus control although the reported CI upper limit is at the null (0.00); certainty of evidence not assessed (no GRADE).
1 finding from 1 review