What do systematic reviews say?

Effects of different delivery devices on growth in children with persistent asthma: Easyhaler‐budesonide vs Turbuhaler‐budesonide

Effects of different delivery devices on growth in children with… may leads to higher change in height (cm) over a period of time compared with turbuhaler‐budesonide (low certainty).

• Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth 2019 · Cochrane Headline outcomes only
  MD 0.37 [0.12, 0.62]
  1 study · 229 participants
  Low

Corticosteroids vs no corticosteroid use

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

• Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
  OR 3.9 [2.31, 6.6]
  21 studies · 9536 participants
  Very low

Corticosteroids vs no corticosteroid use

It is very uncertain whether corticosteroid therapy changes rate of admission to intensive care units compared with no corticosteroid therapy (very low certainty).

• Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
  OR 5.13 [4.26, 6.17]
  1 study · 2141 participants
  Very low

Corticosteroids vs no corticosteroid use

It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).

• Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
  OR 2.74 [1.51, 4.95]
  7 studies · 6114 participants
  Very low

Corticosteroids vs no corticosteroid use

It is very uncertain whether corticosteroid therapy changes proportion of participants requiring mechanical ventilation compared with no corticosteroid therapy (very low certainty).

• Corticosteroids as adjunctive therapy in the treatment of influenza 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 4364 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The intervention showed no clear difference in asthma‐related non‐fatal SAEc (moderate certainty).

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  OR 1.25 [0.72, 2.16]
  8 studies · 8453 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in all‐cause mortality (moderate certainty).

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  OR 0.8 [0.36, 1.78]
  41 studies · 27951 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in all‐cause non‐fatal SAEc (moderate certainty).

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  OR 1.14 [0.97, 1.33]
  41 studies · 27951 participants
  Moderate

Intervention not reported

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  no estimate extracted
  41 studies · 27951 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in asthma‐related non‐fatal SAEc (low certainty).

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  OR 1.15 [0.83, 1.59]
  41 studies · 27951 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 8453 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in all‐cause non‐fatal SAEc (moderate certainty).

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  OR 1.04 [0.73, 1.48]
  8 studies · 8453 participants
  Moderate

Intervention not reported

• Inhaled steroids with and without regular salmeterol for asthma: serious adverse events 2018 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 8453 participants
  Moderate

Intervention not reported

• Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

The review found no eligible studies for this question.

• Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Intervention not reported

• Glucocorticosteroids for infants with biliary atresia following Kasai portoenterostomy 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low