Cochrane · systematic review · CD010126
Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth
Axelsson, I, Naumburg, E, Prietsch, SOM, et al. · Cochrane Database of Systematic Reviews · 2019 · Cochrane Library
AirwaysAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 3 · 60%Moderate 1 · 20%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone versus beclomethasone
Population: children up to 18 years of age with persistent asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Linear growth velocity (cm/year) Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs beclomethasone | MD 0.81 [0.46, 1.16] | 1 study · 23 participants | Low Downgraded: risk of bias, imprecision |
Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone versus budesonide
Population: children up to 18 years of age with persistent asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Linear growth velocity (cm/year) Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide | MD 0.39 | 2 studies · 236 participants | Very low Downgraded: risk of bias, inconsistency |
Change in height (cm) over a period of time Effects of different inhaled corticosteroids on growth in children with persistent asthma: fluticasone vs budesonide | MD 0.97 [0.62, 1.32] | 2 studies · 359 participants | Moderate Downgraded: imprecision |
Effects of different delivery devices on growth in children with persistent asthma: hydrofluoroalkane‐metered dose inhaler beclomethasone versus chlorofluorocarbon‐metered dose inhaler beclomethasone
Population: children up to 18 years of age with persistent asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Linear growth velocity (cm/year) Effects of different delivery devices on growth in children with persistent asthma: hydrofluoroalkane‐metered dose inhaler beclomethasone vs chlorofluorocarbon‐metered dose inhaler beclomethasone | no estimate extracted | 1 study · 212 participants | Low Downgraded: risk of bias, imprecision |
Effects of different delivery devices on growth in children with persistent asthma: Easyhaler‐budesonide versus Turbuhaler‐budesonide
Population: children up to 18 years of age with persistent asthma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Change in height (cm) over a period of time Effects of different delivery devices on growth in children with persistent asthma: Easyhaler‐budesonide vs Turbuhaler‐budesonide | MD 0.37 [0.12, 0.62] | 1 study · 229 participants | Low Downgraded: risk of bias, imprecision |