What do systematic reviews say?

Summary of findings ‐ monotherapy: cavosonstat vs placebo

• Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 26 participants
  Very low

Summary of findings: Compensative interventions vs control

Summary of findings: Compensative interventions may leads to higher adverse events (number of participants with reported events during… compared with control (low certainty).

• Interventions for visual field defects in people with stroke 2019 · Cochrane Headline outcomes only
  OR 5.18
  2 studies · 108 participants
  Low

Summary of findings: Substitutive interventions vs control

Summary of findings: Substitutive interventions may leads to higher adverse events (number of participants with reported events during… compared with control (low certainty).

• Interventions for visual field defects in people with stroke 2019 · Cochrane Headline outcomes only
  OR 87.32 [4.87, 1564.66]
  1 study · 59 participants
  Low

Summary of findings ‐ Hydroxyurea and phlebotomy vs transfusion and chelation

Summary of findings ‐ Hydroxyurea and phlebotomy showed no clear difference in death during the study (all deaths) compared with transfusion and chelation (low certainty).

• Hydroxyurea (hydroxycarbamide) for sickle cell disease 2022 · Cochrane Headline outcomes only
  RR 0.99 [0.06, 15.42]
  2 studies · 254 participants
  Low

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

• Parenteral versus enteral fluid therapy for children hospitalised with bronchiolitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 810 participants
  Moderate

Summary of findings table ‐ Metformin + megestrol vs megestrol

• Metformin for endometrial hyperplasia 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 8 participants
  Very low

Vitamin A vs placebo

Summary of findings table ‐ Vitamin A supplements showed no clear difference in incidence of acute URTIs during the study period (the number of… compared with placebo (low certainty).

• Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age 2024 · Cochrane Headline outcomes only
  RR 1 [0.92, 1.09]
  3 studies · 22668 participants
  Low

Vitamin A vs placebo

• Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age 2024 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 15535 participants
  Low

Summary of findings table for oral immunoglobulin vs control

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period compared with control (low certainty).

• Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates 2016 · Cochrane Headline outcomes only
  RR 0.84 [0.57, 1.25]
  3 studies · 1840 participants
  Low

Summary of findings table for oral immunoglobulin vs control

It is very uncertain whether summary of findings table for oral immunoglobulin changes definite necrotizing enterocolitis (NEC) during study period ‐ IgA/IgG compared with control (very low certainty).

• Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates 2016 · Cochrane Headline outcomes only
  RR 0.08 [0, 1.39]
  1 study · 179 participants
  Very low

Summary of findings table for oral immunoglobulin vs control

Summary of findings table for oral immunoglobulin showed no clear difference in definite necrotizing enterocolitis (NEC) during study period ‐ IgG compared with control (low certainty).

• Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates 2016 · Cochrane Headline outcomes only
  RR 0.95 [0.63, 1.42]
  2 studies · 1661 participants
  Low

Summary of findings table for oral immunoglobulin vs control

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related surgery during study period compared with control (very low certainty).

• Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates 2016 · Cochrane Headline outcomes only
  RR 0.21 [0.02, 1.75]
  2 studies · 311 participants
  Very low

Summary of findings table for oral immunoglobulin vs control

It is very uncertain whether summary of findings table for oral immunoglobulin changes NEC‐related deaths during study period compared with control (very low certainty).

• Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates 2016 · Cochrane Headline outcomes only
  RR 1.1 [0.47, 2.59]
  3 studies · 1840 participants
  Very low

Exercise vs usual care with or without sham interventions

It is very uncertain whether summary of findings table ‐ Exercise interventions changes functional ability: new incidence of delirium during hospitalisation compared with usual care with or without sham interventions (very low certainty).

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  RR 0.9 [0.58, 1.41]
  7 studies · 2088 participants
  Very low

Exercise vs usual care with or without sham interventions

Summary of findings table ‐ Exercise interventions showed no clear difference in falls during hospitalisation compared with usual care with or without sham interventions (moderate certainty).

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  RR 0.99 [0.59, 1.65]
  9 studies · 1787 participants
  Moderate

Exercise vs usual care with or without sham interventions

It is very uncertain whether summary of findings table ‐ Exercise interventions changes medical deterioration during hospitalisation compared with usual care with or without sham interventions (very low certainty).

• Exercise for acutely hospitalised older medical patients 2022 · Cochrane Headline outcomes only
  RR 1.02 [0.62, 1.68]
  11 studies · 2730 participants
  Very low

Summary of findings table ‐ Intravenous paracetamol vs ultracaine paracervical block

• Local anaesthesia for pain control in first trimester surgical abortion 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Moderate

Summary of findings 1. Amorphous hydrogel dressings vs other types of dressings

• Hydrogel dressings for donor sites of split‐thickness skin grafts 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 57 participants
  Very low
• Hydrogel dressings for donor sites of split‐thickness skin grafts 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Very low

Summary of findings table ‐ 20 mL 1% plain lidocaine vs bupivacaine

The review found no eligible studies for this question.

• Local anaesthesia for pain control in first trimester surgical abortion 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ More compressed schedules vs less compressed schedules

The review found no eligible studies for this question.

• Adapting shift work schedules for sleep quality, sleep duration, and sleepiness in shift workers 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found