Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

143 questions · 151 findings · 35 reviews · Headline outcomes only

No studies found 19 · 12.6%GRADE not reported 30 · 19.9%Very low 27 · 17.9%Low 39 · 25.8%Moderate 33 · 21.9%High 3 · 2%

Combination of manual therapy, exercise, electrotherapy and oral NSAID vs oral NSAID

Adverse events Pain persisting longer than 2 hours after treatment (during the 3‐week treatment period) · patients with adhesive capsulitis (frozen shoulder)

Combination of manual therapy, exercise, electrotherapy and oral NSAID may leads to higher adverse events Pain persisting longer than 2 hours after treatment… compared with oral NSAID (low certainty).

1 finding from 1 review

Intervention not reported

Achieved recovery according to predetermined criteria (no longer meeting criteria for depression on K‐SADS or meeting a priori criteria for response on a depression checklist, assessed between 4 and 10 weeks of onset of treatment) · children and adolescents with depression

The intervention showed no clear difference in achieved recovery according to predetermined criteria (no longer… (low certainty).

1 finding from 1 review

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

No clinically important response to treatment ‐ short term · patients with schizophrenia

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes no clinically important response to treatment ‐ short term (3 weeks… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs longer storage duration

Mortality: in‐hospital mortality (within 7 days) · all conditions

It is very uncertain whether transfusion of RBCs of shorter changes mortality: in‐hospital mortality (within 7 days) compared with longer storage duration (very low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults after shorter vs longer durations

Number of participants requiring recatheterisation · adults with short‐term indwelling urethral catheters that need to be removed

Removal of short‐term indwelling urethral catheters in adults after… may leads to higher number of participants requiring recatheterisation compared with longer durations (low certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults after shorter vs longer durations

Symptomatic catheter associated urinary tract infection · adults with short‐term indwelling urethral catheters that need to be removed

Removal of short‐term indwelling urethral catheters in adults after… probably leads to lower symptomatic catheter associated urinary tract infection (CAUTI) Â compared with longer durations (moderate certainty).

1 finding from 1 review

Removal of short‐term indwelling urethral catheters in adults after shorter vs longer durations

Dysuria · adults with short‐term indwelling urethral catheters that need to be removed

Removal of short‐term indwelling urethral catheters in adults after… may leads to lower dysuria compared with longer durations (low certainty).

1 finding from 1 review