Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Serum 25(OH)D <50 nmol/l (vs ≥75 nmol/l) was associated with higher odds of ECC (OR 2.00; ungraded).
1 finding from 1 review
Intervention not reported
Dental caries (early childhood caries)
The intervention led to lower dental caries (early childhood caries); GRADE not reported.
1 finding from 1 review
Intervention not reported
Dental caries (early childhood caries)
1 finding from 1 review
AOR 6.5
1 study
GRADE not reported
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <18 vs ≥18 months was associated with significantly fewer caries (RR 0.41, 95% CI 0.18-0.92; substantial heterogeneity; ungraded).
2 findings from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Serum 25(OH)D 50–75 nmol/l (vs ≥75 nmol/l) was associated with higher odds of ECC (OR 1.42; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children (<6 years)
Breastfeeding for <4 vs ≥4 months was not significantly associated with early childhood caries (RR 0.95, 95% CI 0.80-1.13; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Children with average age ≤3 years
No significant association between cesarean vs vaginal delivery and ECC among children with average age ≤3 years (OR 0.86, 95% CI 0.67-1.10).
1 finding from 1 review
OR 0.86 [0.67, 1.10]
10 studies
GRADE not reported
Early childhood caries (ECC) · Preschool children (<6 years)
In cohort studies, breastfeeding for <6 vs ≥6 months was not significantly associated with early childhood caries (RR 0.97, 95% CI 0.88-1.06; ungraded).
2 findings from 1 review
Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)
Serum 25(OH)D <50 nmol/l (vs 50–75 nmol/l) was associated with higher odds of ECC (OR 1.47; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children ≤6 years, North America
In North America, 25(OH)D 50–75 nmol/l (vs ≥75) was associated with higher odds of ECC (OR 2.09; ungraded).
1 finding from 1 review
Early childhood caries (ECC) · Preschool children ≤6 years, Asia and Europe
In Asia and Europe, 25(OH)D 50–75 nmol/l (vs ≥75) was associated with higher odds of ECC (OR 1.32; ungraded).
1 finding from 1 review
Intervention not reported
Dental caries (early childhood caries)
1 finding from 1 review
AOR 3.7
1 study
GRADE not reported
Intervention not reported
Dental caries (early childhood caries)
1 finding from 1 review
AOR 6.7
1 study
GRADE not reported
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
No significant difference in caries odds was found between mixed breast-and-bottle-fed and bottle-fed-only children (meta-analysis reported no difference; pooled estimate in an unavailable supplementary figure; not GRADE-rated).
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of TAS2R43 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of TAS2R43 was significantly associated with ECC in the TWAS (p = 8.78e-8); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association with genetically predicted expression of SMIM10L1 (chr12p13.2) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
Genetically predicted expression of SMIM10L1 was significantly associated with ECC in the TWAS (p = 1.70e-7); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs76823412 (8:134690570; nearest gene(s) ST3GAL1) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs8091366 near CHST9, KCTD1 showed suggestive (not genome-wide significant) association with ECC (Z = 4.476, p = 7.60e-6); genetic association, ungraded.
2 findings from 1 review
Early childhood caries (ECC) - association at lead SNP rs563135 (10:115067899; nearest gene(s) TCF7L2, CASP7) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs563135 near TCF7L2, CASP7 showed suggestive (not genome-wide significant) association with ECC (Z = -4.532, p = 5.86e-6); genetic association, ungraded.
1 finding from 1 review
Early childhood caries (ECC) - association at lead SNP rs1044956 (7:24854765; nearest gene(s) OSBPL3, NPVF) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5 cohorts (N=2974)
The common variant rs1044956 near OSBPL3, NPVF showed suggestive (not genome-wide significant) association with ECC (Z = 4.551, p = 5.35e-6); genetic association, ungraded.
2 findings from 1 review
Early childhood caries (ECC) · Healthy children under 6 years in South Africa
Parental tertiary education (vs high-school education) was associated with about 1.8 times higher odds of early childhood caries in South Africa (OR 1.77, 95% CI 1.22-2.57; 2 studies; not GRADE-rated).
1 finding from 1 review