Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

175 questions · 177 findings · 31 reviews

No studies found 18 · 10.2%GRADE not reported 33 · 18.6%Very low 50 · 28.2%Low 57 · 32.2%Moderate 19 · 10.7%High 0 · 0%

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Improvement in nutritional intake · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Improvement of pre-existing accompanying symptoms other than pain · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Mortality rate and cause of death · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events ‐ recurrent fever · acute bacterial meningitis

The intervention probably leads to higher adverse events ‐ recurrent fever (moderate certainty).

1 finding from 1 review

Higher drinking-water fluoride exposure vs Lower water fluoride concentration (concurrent control)

Dental fluorosis of aesthetic concern (Dean's Index, TFI, TSIF) · Populations of all ages (mostly children) exposed to drinking water with differing fluoride concentrations

Higher water fluoride concentration (fluoridated water; natural or… may leads to higher dental fluorosis of aesthetic concern (Dean's Index, TFI, TSIF) compared with lower water fluoride concentration (concurrent control) (low certainty).

1 finding from 1 review

Higher drinking-water fluoride exposure vs Lower water fluoride concentration (concurrent control)

Adverse effects: dental fluorosis · Populations of all ages (mostly children) exposed to drinking water with differing fluoride concentrations

Higher water fluoride concentration (fluoridated water; natural or… may leads to higher dental fluorosis of any level (all severities) compared with lower water fluoride concentration (concurrent control) (low certainty).

1 finding from 1 review

Topical triamcinolone acetonide vs pimecrolimus 1%

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in adverse effects compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review

Clobetasol propionate plus miconazole (adjunctive antifungal) vs Clobetasol propionate plus placebo

Candidosis (adverse effect) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Topical clobetasol propionate vs Topical ciclosporin

Pain resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes pain resolution compared with topical ciclosporin (very low certainty).

1 finding from 1 review

Topical clobetasol propionate vs Topical tacrolimus

Pain (mean VAS score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical clobetasol propionate showed no clear difference in pain (mean VAS score) compared with topical tacrolimus; GRADE not reported.

1 finding from 1 review

Topical clobetasol propionate vs Topical tacrolimus

Clinical resolution · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes clinical resolution compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Oral prednisone plus curcuminoids (adjunctive) vs Oral prednisone plus placebo

Reduction in pain · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment
1 finding from 1 review

Topical triamcinolone acetonide vs Intralesional BCG-polysaccharide nucleic acid (BCG-PSN)

Pain (mean score) · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in pain (mean score) compared with intralesional BCG-polysaccharide nucleic acid (BCG-PSN); GRADE not reported.

1 finding from 1 review