Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

289 questions · 295 findings · 34 reviews

No studies found 37 · 12.5%GRADE not reported 10 · 3.4%Very low 103 · 34.9%Low 66 · 22.4%Moderate 65 · 22%High 14 · 4.7%

Summary of findings ‐ withdrawal of penicillin prophylaxis vs continuation

Requirement of other courses of antibiotics · children with SCD who have been receiving prophylactic penicillin for at least two years

Summary of findings ‐ withdrawal of penicillin prophylaxis showed no clear difference in requirement of other courses of antibiotics compared with continuation (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

All cause‐mortality · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Febrile patients and episodes · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower febrile patients and episodes compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Antibiotics vs other antibiotics

Clinical diagnosis of leptospirosis regardless of laboratory confirmation · farmworkers

It is very uncertain whether summary of findings table ‐ Antibiotics changes clinical diagnosis of leptospirosis regardless of laboratory… compared with other antibiotics (very low certainty).

1 finding from 1 review