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Evidence found and GRADE certainty

1,192 questions · 1,243 findings · 151 reviews

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No studies found 252 · 20.3%GRADE not reported 180 · 14.5%Very low 291 · 23.4%Low 282 · 22.7%Moderate 174 · 14%High 64 · 5.1%

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 hours · Adults with acute pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 hours (high certainty).

1 finding from 1 review

Intervention not reported

Participants remedicating within 8 hours · Adults with acute pain

The intervention leads to lower participants remedicating within 8 hours (high certainty).

1 finding from 1 review

Intervention not reported

Participants with at least 1 adverse event (all diclofenac potassium doses, 25 mg to 100 mg) · Adults with acute pain

The intervention showed no clear difference in participants with at least 1 adverse event (all diclofenac potassium… (moderate certainty).

1 finding from 1 review

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 h · adults with moderate or severe acute postoperative pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 h (high certainty).

1 finding from 1 review

Intervention not reported

Participants with at least 1 adverse event · adults with moderate or severe acute postoperative pain

The intervention showed no clear difference in participants with at least 1 adverse event (moderate certainty).

1 finding from 1 review

Etomidate vs all other induction agents

ACTH stimulation test ACTH stimulation test is considered positive if the change in serum cortisol level was less than 9 μg/dL (248 nmol/L) after the administration of 250 μg of cosyntropin · patients with endotracheal intubation in critically ill patients

Etomidate probably leads to higher ACTH stimulation test ACTH stimulation test is considered positive… compared with all other induction agents (moderate certainty).

1 finding from 1 review

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 h · Adults with acute pain

The intervention probably leads to higher at least 50% of maximum pain relief over 4 to 6 h (moderate certainty).

1 finding from 1 review

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 hours (high certainty).

1 finding from 1 review