Etomidate vs all other induction agents: ACTH stimulation test ACTH stimulation test is considered positive if the change in serum cortisol level was less than 9 μg/dL (248 nmol/L) after the administration of 250 μg of cosyntropin
Etomidate probably leads to higher ACTH stimulation test ACTH stimulation test is considered positive… compared with all other induction agents (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Etomidate vs all other induction agents ACTH stimulation test ACTH stimulation test is considered positive if the change in serum cortisol level was less than 9 μg/dL (248 nmol/L) after the administration of 250 μg of cosyntropin · patients with endotracheal intubation in critically ill patients Etomidate probably leads to higher ACTH stimulation test ACTH stimulation test is considered positive… compared with all other induction agents (moderate certainty). Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically… (2015) · Cochrane Headline outcomes only | OR 2.37 [1.61, 3.47] | 3 studies · 519 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Single induction dose of etomidate versus other induction agents for endotracheal intubation in critically ill patients 2015 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.