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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) probably leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) may leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with promethazine oral (1 mg/kg) (low certainty).

1 finding from 1 review