Cochrane · systematic review · CD011675
Wound cleansing for treating venous leg ulcers
McLain, NEM, Moore, ZEH, Avsar, P · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
WoundsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
28
current version
GRADE rated
9
No studies
19
Included studies
NR
No studies 19 · 67.9%Ungraded 0 · 0%Very low 9 · 32.1%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Polyhexamethylene biguanide (PHMB) versus 0.9% saline solution
Population: participants with venous leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to healing Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Number of wounds healed Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Change in ulcer size over time Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Pain Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Cost Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Health related quality of life Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Adverse events Polyhexamethylene biguanide (PHMB) vs 0.9% saline solution | no estimate extracted | NR | No studies |
Aqueous oxygen peroxide versus sterile water
Population: participants with venous leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to healing Aqueous oxygen peroxide vs sterile water | no estimate extracted | NR | No studies |
Number of wounds healed ‐ per protocol ‐ after 12 months of Aqueous oxygen peroxide vs sterile water | RR 1.88 [1.1, 3.2] | 1 study · 34 participants | Very low Downgraded: risk of bias, imprecision |
Change in ulcer size (surface area changes in cm2 from baseline) ‐ ITT ‐ after 8 weeks of Aqueous oxygen peroxide vs sterile water | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Procedural pain (pain measured using a 0 to 10 cm Likert scale, which gives a 0–100 pain rating (0 = no pain, 100 = very painful) ‐ ITT ‐ after 8 weeks of Aqueous oxygen peroxide vs sterile water | no estimate extracted | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Cost Aqueous oxygen peroxide vs sterile water | no estimate extracted | NR | No studies |
Health related quality of life Aqueous oxygen peroxide vs sterile water | no estimate extracted | NR | No studies |
Adverse events Aqueous oxygen peroxide vs sterile water | no estimate extracted | NR | No studies |
Propyl betaine and polihexanide versus saline solution
Population: participants with chronic leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to healing Propyl betaine and polihexanide vs saline solution | no estimate extracted | NR | No studies |
Number of wounds healed Propyl betaine and polihexanide vs saline solution | no estimate extracted | NR | No studies |
Change in ulcer size after 4 weeks of Propyl betaine and polihexanide vs saline solution | no estimate extracted | 1 study · 38 participants | Very low Downgraded: risk of bias, imprecision |
Procedural pain after 4 weeks of follow‐ up (self‐assessed, subjectively, using a validated 10‐mm visual analogue scale) Propyl betaine and polihexanide vs saline solution | no estimate extracted | 1 study · 38 participants | Very low Downgraded: risk of bias, imprecision |
Cost Propyl betaine and polihexanide vs saline solution | no estimate extracted | NR | No studies |
Health related quality of life Propyl betaine and polihexanide vs saline solution | no estimate extracted | NR | No studies |
Adverse events after 4 weeks of Propyl betaine and polihexanide vs saline solution | no estimate extracted | 1 study · 38 participants | Very low Downgraded: risk of bias, imprecision |
OHP versus Ringer's solution for treating venous leg ulcers
Population: participants with treating venous leg ulcers
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to complete wound healing OHP vs Ringer's solution | no estimate extracted | NR | No studies |
Number of wounds healed after 12 weeks of OHP vs Ringer's solution | RR 0.96 [0.53, 1.72] | 1 study · 99 participants | Very low Downgraded: risk of bias, imprecision |
Change in ulcer size over time (cm2) after week 12 of OHP vs Ringer's solution | no estimate extracted | 1 study · 99 participants | Very low Downgraded: risk of bias, imprecision |
Procedural pain OHP vs Ringer's solution | no estimate extracted | NR | No studies |
Cost OHP vs Ringer's solution | no estimate extracted | NR | No studies |
Health related quality of life OHP vs Ringer's solution | no estimate extracted | NR | No studies |
Adverse events after week 12 of OHP vs Ringer's solution | RR 0.58 [0.29, 1.14] | 1 study · 126 participants | Very low Downgraded: risk of bias, imprecision |