MMP-9 expression/activity · Human carious dentin
No difference in MMP-9 expression/activity was found before versus after cavity sealing (very low certainty).
1 finding from 1 review
Prevalence of white spot lesions (WSL) at debonding, subject level · Healthy adolescents and adults undergoing orthodontic treatment with fixed multi-bracket appliances
Fluoride varnish applied regularly during fixed orthodontic treatment may reduce the prevalence of white spot lesions at debonding (pooled RR 0.64, 95% CI 0.42 to 0.98), but the certainty of evidence is very low.
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
Studies not reported
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Completing orthodontic treatment is associated with improved OHRQoL in adolescents (narrative synthesis; included reviews report low-to-moderate certainty; no pooled estimate or GRADE rating by the umbrella review).
1 finding from 1 review
Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomesCommunity/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
Adolescents who had never received orthodontic treatment had a greater impact on quality of life compared to patients who had already completed treatment [34, 40, 44-46]. Orthodontic treatment during childhood or…
Studies not reported
GRADE not reported
Oral health-related quality of life · Indian elderly and general-population adults
Prosthetic need was significantly associated with poorer OHRQoL in both included studies (moderate certainty).
3 findings from 1 review
Prosthetic need vs none: both included studies showed a significant association with poor QoL (Nagarajappa 2015, Shivakumar 2018); 950 participants, 2 observational studies; Moderate certainty (Fig 1 GRADE SoF). No…
2 studies · 950 participants
Moderate
Prosthetic need and QoL (continuous, OHIP-14): prosthetic need was significantly related to various components of OHRQoL (Joseph 2016). Single study, not pooled.
1 study
GRADE not reported
Prosthetic need and QoL (continuous, GOHAI): of three studies, one found no significant difference (Shetty 2013) and two proved the association (Pillai 2015, Rekhi 2018). Not pooled.
3 studies
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
Tooth loss/edentulism is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Severity of white spot lesions (surface area and depth) · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
White spot lesion severity was assessed narratively in a small number of studies and not meta-analyzed; evidence is limited (ungraded).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 2 or more years in permanent teeth, secondary caries did not differ significantly between fluoride-containing amalgam and GIC (RR 0.95, 95% CI 0.45-2.00; low certainty).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Bruxism was not shown to impact OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
2 findings from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported that dental erosion has not been shown to affect oral health-related quality of life.
2 findings from 1 review
Poor oral health-related quality of life (OHRQoL) · Indians
Prosthetic need is associated with poor OHRQoL (moderate certainty).
1 finding from 1 review
Bacterial collagenolytic protease gene expression · Human ex vivo carious lesions / caries-associated biofilm
Genes encoding bacterial collagenolytic proteases were detected/overexpressed in coronal and root caries (ungraded; GRADE not feasible).
1 finding from 1 review
Genes coding for bacterial collagenolytic proteases were significantly expressed/overrepresented in coronal (Simon-Soro et al., 2013) and root (Dame-Teixeira et al., 2018: 42 proteases differentially expressed, 18…
2 studies · 25 participants
GRADE not reported
CA VI activity · Children (age about 2-9 years) across the 7 meta-analyzed activity samples; excludes Kivela 1999 adults (18-24 years), qualitative only…
Salivary/biofilm CA VI activity is significantly higher in individuals with dental caries than in caries-free individuals (SMD 0.894, 95% CI 0.386 to 1.392; not GRADE-rated).
1 finding from 1 review
Adverse events (participants with >=1 adverse event) · Adults with Parkinson's disease and sialorrhea (drooling)
Type A botulinum toxin showed a borderline, non-significant increase in adverse events versus placebo (RD 0.10, 95% CI 0.00 to 0.21; ungraded subgroup).
3 findings from 1 review
restoration and caries status · children with caries in permanent molars
The review reported SDF was beneficial for arresting caries; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Oral health-related quality of life · Indian children and young adults
Two studies found dental fluorosis significantly associated with poorer OHRQoL; narrative, ungraded.
1 finding from 1 review
Dental fluorosis and QoL (continuous, OIDP/CPQ11-14): a significant difference between individuals with and without fluorosis on OHRQoL (Nagarajappa 2015, Shyam 2020). Two studies, 3000 individuals; not pooled.
2 studies · 3000 participants
GRADE not reported
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
Over 2 or more years in deciduous teeth, secondary caries did not differ significantly between resin composite and RMGIC (RR 1.60, 95% CI 0.85-3.00; low certainty).
1 finding from 1 review
Shear bond strength (SBS) of metallic orthodontic brackets · Demineralized enamel of extracted permanent human teeth
When used to remineralize white spot lesions on demineralized enamel, CPP-ACP pre-treatment did not significantly affect shear bond strength (MD 1.501, 95% CI -0.630 to 3.632; ungraded).
1 finding from 1 review
MD 1.501 [-0.630, 3.632]
9 studies
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported better oral health-related quality of life with favorable housing, parental education, income, family environment, and access to dental care.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Secondary caries · Patients requiring dental restoration; deciduous (primary) teeth
In deciduous teeth at 1 year, secondary caries did not differ significantly between compomer and resin composite, with high heterogeneity (RR 0.41, 95% CI 0.02-8.34; I2=83%; ungraded).
1 finding from 1 review