Salivary flow rate · Elderly (>60 years) and medically compromised adults with xerostomia / dry mouth
Across 19 studies the effect of gum chewing on stimulated and/or unstimulated salivary flow rate was mixed (9 positive, 10 no effect); this broad outcome was not meta-analyzed.
1 finding from 1 review
The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a… 2023 All outcomesVarious (single session to 12 months) · Haemodialysis units, elderly / geriatric care, cancer and palliative care, and xerostomia / hyposalivation clinics (studies from multiple countries)
Narrative vote-count: of 19 studies measuring stimulated and/or unstimulated saliva flow rate, 9 found a positive effect of gum chewing [17,18,22,24,27,35,36,38,39] and 10 detected no effect…
19 studies
GRADE not reported
Predictive performance for coronal caries increment (negative likelihood ratio, LR-) · Children and adolescents (aged 2-19) at risk of coronal caries increment (caries onset or progression)
Some developmental coronal-caries models achieved useful negative likelihood ratios (LR-<=0.20), but performance varied widely; no pooled estimate; ungraded.
2 findings from 1 review
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up >=1 year (included studies 1-5 years) · Oral health care; children/adolescents; no geographical restriction · Model development studies
No meta-analysis. Per-model LR- (Table 2) for the 8 development studies ranged roughly 0.11-0.94 (e.g. Angulo 0.94, Demers 0.14-0.40, Gao 2010 0.11-0.30). Overall across all 66 models LR- ranged 0.0-1.1; LR-<=0.20…
8 studies
GRADE not reported
Multivariable prediction models of caries increment: a systematic review and critical appraisal. 2023 All outcomesFollow-up >=1 year (included studies 1-5 years) · Oral health care; children/adolescents; no geographical restriction · Model validation studies
No meta-analysis. Per-model LR- (Table 2) across the 9 validation studies ranged from about 0.14 to 1.13 (e.g. Gao 2013 NUS-CRA 0.26, CAMBRA 0.14-0.31, CAT up to ~1.10; Campus 0.20; Pang 2020 low-risk 1.13). Overall…
9 studies
GRADE not reported
MMP-8 expression/activity · Human carious dentin
MMP-8 may be increased before compared with after cavity sealing (very low certainty).
1 finding from 1 review
Pulp necrosis · Vital teeth
The pooled incidence with GIC permanent cement was 5.33%.
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
P11-4 plus fluoride varnish was significantly better than fluoride varnish alone (SMD -0.71, 95% CI -1.13 to -0.29); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Dental caries · Children (<19 years)
Children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels (unadjusted RR 1.22; ungraded).
5 findings from 1 review
Show 2 more findings
RR 1.16 [1.10, 1.22]
Studies not reported
GRADE not reported
RR 1.05 [1.00, 1.09]
3 studies
GRADE not reported
Reduction in frequency and severity of drooling · Adults with Parkinson's disease and sialorrhea (drooling)
Type A botulinum toxin significantly reduced DSFS scores versus placebo (SMD -0.80, 95% CI -1.25 to -0.36; ungraded subgroup).
3 findings from 1 review
Body‐mass index z score (zBMI) · Children aged 1–6 years
The review reported lower body mass index-for-age z scores in children with pulp-involved caries.
1 finding from 1 review
Dental caries · Children with permanent dentition (>12 years)
In children with permanent dentition, vitamin D deficiency was associated with a 28% higher caries risk (RR 1.28; ungraded).
1 finding from 1 review
RR 1.28 [1.21, 1.35]
2 studies
GRADE not reported
Poor oral health-related quality of life (OHRQoL) · Indians
Malocclusion is associated with poor OHRQoL but certainty is very low.
1 finding from 1 review
MMP-8 expression/activity · Human coronal carious dentin and sound dentin
No effect direction was found for MMP-8 in carious versus sound dentin (very low certainty).
1 finding from 1 review
no estimate extracted
2 studies
Very low
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth of mixed/unspecified root maturation
In mixed-maturation teeth, the effect of MTA versus calcium hydroxide on success is very uncertain (OR 1.11, 95% CI 0.17-7.11; very low certainty).
1 finding from 1 review
New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars
Resin sealant gave a 65% prevented fraction (fissure site) vs water, the highest fissure-site value (p<0.002; ungraded).
2 findings from 1 review
Dental caries · Children with deciduous dentition (<6 years)
In children with deciduous dentition, vitamin D deficiency was associated with a 68% higher caries risk (RR 1.68; ungraded).
1 finding from 1 review
RR 1.68 [1.57, 1.79]
6 studies
GRADE not reported
Tooth discoloration · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
More tooth discoloration was observed with MTA than with Biodentine, but odds ratios were implausibly large and not pooled (3 RCTs; ungraded).
1 finding from 1 review
Gingival inflammation-related index · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Short-term fluoride mouthwash has uncertain effects on gingival inflammation-related indexes versus blank control (very low certainty).
1 finding from 1 review
MMP-2 presence/activity · Human ex vivo carious dentin
MMP-2 shows no difference between root and coronal carious dentin; the evidence is very uncertain (very low certainty).
1 finding from 1 review
There is no difference in MMP-2 activity in root vs. coronal carious dentin; MMP-2 was present in both coronal and root dentin in all specimens (Toledano et al., 2010). The evidence is very uncertain.
1 study · 10 participants
Very low
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · Patients with white spot lesions / early caries lesions (WSLs/ECLs), including orthodontic and non-orthodontic lesions, active caries…
Resin infiltration was significantly better than CPP-ACP (SMD -0.77, 95% CI -1.31 to -0.23); certainty of evidence not assessed (no GRADE).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
Severe periodontal disease is associated with worse OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
Change in height-for-age z score · Preschool children (<6 years)
The review reported an unadjusted negative association between baseline caries and change in height-for-age z score.
1 finding from 1 review