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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
75,239 questions in 5,342 reviews
current versionsNo studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Intervention NR EACA given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR Fibrin (topical) · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR TXA given intravenously at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Moderate |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Moderate |
Intervention NR TXA given intravenously at a total dose of 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Moderate |
Intervention NR TXA given orally at a total dose of 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR Total studies: 19 Total participants: 2395 · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 19 participants | Ungraded |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of 2 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intra‐articularly at a total dose of 2 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given orally and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Very low |
Intervention NR Aprotinin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | NR | Very low |
Intervention NR TXA given intra‐articularly at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously at a total dose of 2 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Moderate |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of 2 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 2 participants | Moderate |
Intervention NR TXA given intravenously and orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Intervention NR TXA given intravenously at a total dose of 1 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 1 participants | Low |
Intervention NR TXA given intravenously and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,… Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane | no estimate extracted | 3 participants | Low |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Child health, functioning, and quality of life Pediatric Quality of Life Inventory (PedsQL) · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | 3 studies · 701 participants | Low |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Parent health, functioning, and quality of life Patient‐Reported Outcomes Measurement Information System (PROMIS) (higher scores = more of the outcome of interest, which can mean improvement or deterioration depending on the outcome) · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | 1 study · 207 participants | Moderate |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Child and family satisfaction with, and perceptions of, care and service delivery Family Experiences With Coordination of Care (FECC) survey (higher scores = better) Consumer Assessment of Healthcare Providers and Systems (CAHPS) (higher scores = ... · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | 3 studies · 701 participants | Low |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Number of healthcare encounters: ED visits ( · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | 3 studies · 739 participants | Moderate |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Number of hospitalised days (hospital admissions) ( · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | 3 studies · 739 participants | Moderate |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Costs to the healthcare system ( · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | 3 studies · 739 participants | Low |
Summary of findings for the main comparison: comprehensive care programmes vs usual care Costs to the family · children with medical complexity Comprehensive care programmes for children with medical complexity (2024) · Cochrane | no estimate extracted | NR | No studies |
Facilitated tucking / four‐handed care / gentle human touch vs standard care Validated pain scales · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | NR | No studies |
Familiar odour (breast milk smell) vs standard care Validated pain scores · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | NR | No studies |
Familiar odour (breast milk smell) vs standard care PIPP during endotracheal suctioning Range of scale 0 to 21. Lower score = less pain · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |
Familiar odour (breast milk smell) vs standard care Physiological indicators · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | NR | No studies |
Familiar odour (breast milk smell) vs standard care Heart rate · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |
Familiar odour (breast milk smell) vs standard care SaO 2 during endotracheal suctioning · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |
Familiar odour (breast milk smell) vs standard care Behavioural indicators · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | NR | No studies |
Familiar odour (breast milk smell) vs standard care — · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | NR | No studies |
White noise vs standard care Validated pain scores · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | NR | No studies |
White noise vs standard care PIPP during endotracheal suctioning Range of scale 0 to 21 Lower score = less pain · neonates with mechanical ventilation Non‐pharmacological interventions for the prevention of pain during endotracheal suctioning in ventilated… (2024) · Cochrane | no estimate extracted | 1 study · 40 participants | Low |