Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Surgical thrombectomy vs continuous infusion
Technical Success · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.41 [0.96, 2.06]1 study · 31 participantsVery low
Surgical thrombectomy vs continuous infusion
Access dysfunction · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs continuous infusion
Successful dialysis · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs continuous infusion
Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.13 [0.01, 2.4]1 study · 31 participantsVery low
Surgical thrombectomy vs continuous infusion
Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.19 [0.02, 1.43]1 study · 31 participantsVery low
Surgical thrombectomy vs pulse spray technique
Access dysfunction · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs continuous infusion
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Continuous Infusion vs pulse spray technique
Patency at 30 days · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.92 [0.67, 1.27]1 study · 30 participantsVery low
Continuous Infusion vs pulse spray technique
Failure · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Continuous Infusion vs pulse spray technique
Technical success · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.07 [0.89, 1.28]1 study · 30 participantsVery low
Continuous Infusion vs pulse spray technique
Access dysfunction · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Continuous Infusion vs pulse spray technique
Successful dialysis · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Continuous Infusion vs pulse spray technique
Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Continuous Infusion vs pulse spray technique
Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1 [0.07, 14.55]1 study · 30 participantsVery low
Continuous Infusion vs pulse spray technique
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Patency at 30 days · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs pulse spray technique
Successful dialysis · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Failure · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Technical success · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.96 [0.87, 1.06]1 study · 77 participantsVery low
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Access dysfunction · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Successful dialysis · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.98 [0.41, 9.57]1 study · 77 participantsVery low
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.58 [0.15, 16.71]1 study · 77 participantsVery low
Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs different types of endovascular interventions
Patency at 30 days · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.1 [0.73, 1.65]1 study · 115 participantsVery low
Surgical thrombectomy vs different types of endovascular interventions
Failure · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.66 [0.23, 1.89]1 study · 115 participantsVery low
Surgical thrombectomy vs different types of endovascular interventions
Technical success · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.15 [0.94, 1.41]1 study · 115 participantsVery low
Surgical thrombectomy vs pulse spray technique
Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.33 [0.02, 7.32]1 study · 20 participantsVery low
Surgical thrombectomy vs different types of endovascular interventions
Access dysfunction · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs different types of endovascular interventions
Successful dialysis · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs different types of endovascular interventions
Major adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 0.35 [0.01, 8.44]1 study · 115 participantsVery low
Surgical thrombectomy vs different types of endovascular interventions
Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 5.26 [0.26, 107.27]1 study · 115 participantsVery low
Surgical thrombectomy vs different types of endovascular interventions
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs pulse spray technique
Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs pulse spray technique
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
no estimate extractedNRNo studies
Surgical thrombectomy vs mechanical thrombectomy
Patency at 30 days · thrombosed haemodialysis arteriovenous fistulas and grafts
Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts (2024) · Cochrane
RR 1.34 [1.07, 1.67]3 studies · 404 participantsVery low
Intervention NR
Total studies: 47 Total participants: 4398 · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted47 participantsUngraded
Intervention NR
TXA given intra‐articularly at a total dose of 2 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted2 participantsLow
Intervention NR
TXA given intravenously at a total dose of 1 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted1 participantsLow
Intervention NR
TXA given orally at a total dose of greater than 3 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted3 participantsVery low
Intervention NR
TXA given orally at a total dose of 2 g pre‐incision · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted2 participantsLow
Intervention NR
TXA given intra‐articularly at a total dose of 1 g intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted1 participantsLow
Intervention NR
TXA given intravenously at a total dose of greater than 3 g intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted3 participantsModerate
Intervention NR
TXA given intravenously and intra‐articularly at a total dose of 2 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted2 participantsVery low
Intervention NR
TXA given orally at a total dose of 2 g pre‐incision and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted2 participantsLow
Intervention NR
TXA given intravenously at a total dose of 2 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted2 participantsVery low
Intervention NR
TXA given intravenously at a total dose of 1 g pre‐incision and intraoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted1 participantsModerate
Intervention NR
TXA given orally and intra‐articularly at a total dose of greater than 3 g pre‐incision, intraoperatively and postoperatively · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extracted3 participantsModerate
Intervention NR
Aprotinin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extractedNRLow
Intervention NR
Desmopressin given intravenously · individuals undergoing planned hip or knee replacement surgery Interventions: antifibrinolytics (tranexamic acid,…
Pharmacological interventions for the prevention of bleeding in people undergoing elective hip or knee… (2024) · Cochrane
no estimate extractedNRLow