Early childhood caries (ECC) · Children aged ≤6 years (early childhood)
One Nigerian cross-sectional study reported a significant adjusted association between nutritional (stunting) status and ECC (APR 0.14, 95% CI 0.03-0.69); ungraded.
4 findings from 1 review
APR 0.14 [0.03, 0.69]
1 study · 370 participants
GRADE not reported
Correlation (r) -0.091
1 study · 82 participants
GRADE not reported
The bi-directional relationship between growth stunting and early childhood caries: a rapid review. 2023 All outcomes2-year follow-up · Ecuador (rural) · Sokal-Gutierrez et al. 2016 (Ecuador; pre vs post intervention)
Pre/post ECC prevalence, dmft, and deep-caries proportion (2-year follow-up) Age 1: prevalence 53.8% to 30.3%, dmft 2.1 to 0.9; Age 2: prevalence 82% to 60%, dmft 5.3 to 3.0, deep caries 19% to 12% (pre vs post)
1 study · 1575 participants
GRADE not reported
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Oral health-related quality of life · Adolescents (10-19 years)
Complicated traumatic dental injuries (pulp exposure or tooth darkening) worsen OHRQoL in adolescents, while uncomplicated injuries show little impact (narrative synthesis; no pooled estimate or GRADE rating).
1 finding from 1 review
MMP-2 presence/activity · Human coronal carious dentin and sound dentin
MMP-2 may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
Secondary caries · Patients requiring dental restoration; permanent teeth
Over 1 year in permanent teeth, resin composite showed no statistically significant difference in secondary caries versus GIC (RR 3.05, 95% CI 0.95-9.79; low certainty).
2 findings from 1 review
Plaque · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Herbal mouthwash reduced some plaque-related indices versus placebo, with low-certainty evidence.
1 finding from 1 review
MMP-9 presence/activity · Human coronal carious dentin and sound dentin
MMP-9 may be increased in carious dentin compared with sound dentin (very low certainty).
1 finding from 1 review
no estimate extracted
3 studies
Very low
Cariogenic bacteria (Mutans streptococci) · People undergoing orthodontic treatment (any age; 9 to 34 years in included studies)
Short-term fluoride mouthwash reduced Mutans streptococci, but certainty is very low.
2 findings from 1 review
Probing pocket depth (PPD/PD) · Orthodontic patients (any age) undergoing orthodontic treatment (mostly fixed appliances)
Chlorhexidine mouthwash may reduce pocket probing depth versus placebo in the short term (low certainty).
1 finding from 1 review
White spot lesion incidence · Orthodontic patients undergoing comprehensive treatment (late mixed or permanent dentition, no active caries)
Most studies reported a lower incidence of white spot lesions with clear aligners than fixed appliances, but heterogeneous assessment methods precluded meta-analysis (ungraded).
1 finding from 1 review
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported that malocclusion negatively affects oral health-related quality of life.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Oral health-related quality of life · Adolescents (10-19 years)
The umbrella review reported worse oral health-related quality-of-life scores with severe periodontitis.
1 finding from 1 review
no estimate extracted
Studies not reported
GRADE not reported
Intervention not reported
Oral health practices
1 finding from 1 review
Pulp necrosis · Vital teeth
One study reported a 13% incidence in teeth with pre-operative caries fillings or crowns.
2 findings from 1 review
Proportion 13
1 study
GRADE not reported
Proportion 5
1 study
GRADE not reported
MMP-9 presence/activity · Human ex vivo carious dentin (mostly coronal), natural caries lesions
MMP-9 may be increased in carious dentin compared with sound dentin, but the evidence is very uncertain (very low certainty).
1 finding from 1 review
MMP-9 may be increased in carious dentin when compared to sound dentin, but the evidence is very uncertain.
3 studies · 292 participants
Very low
New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time SDF within a brushing programme did not significantly reduce caries vs control (p>0.05; ungraded).
2 findings from 1 review
Secondary prevention of caries · children with deep occlusal carious lesions in permanent molars
No significant difference in secondary caries prevention was reported; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Predictive performance for root caries increment (positive likelihood ratio, LR+) · Older adults (aged 52-95; mean 52-73) at risk of root caries increment
Developmental root-caries prediction models were generally modest, except Sanchez-Garcia 2011 (LR+ 7.09) which reached the useful threshold; no pooled estimate; ungraded.
2 findings from 1 review
MMP-2 activity · Human root and coronal carious dentin
No difference in MMP-2 activity was found in root versus coronal carious dentin (very low certainty).
1 finding from 1 review
Periapical pathosis incidence · Vital teeth
One study reported a 1.4% incidence with bone level < 35%.
2 findings from 1 review
Proportion 1.4
1 study
GRADE not reported
Proportion 0
1 study
GRADE not reported
Oral health-related quality of life · Indians
In adolescents (10-19 years), dental caries was associated with poorer OHRQoL (pooled OR 3.92; 5 studies); ungraded.
5 findings from 1 review
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