What do systematic reviews say?

Prefabricated foot orthoses vs shoes

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Low

Prefabricated foot orthoses vs shoes

The review found no eligible studies for this question.

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prefabricated foot orthoses vs shoes

The review found no eligible studies for this question.

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prefabricated foot orthoses vs shoes

The review found no eligible studies for this question.

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prefabricated foot orthoses vs shoes

The review found no eligible studies for this question.

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Prefabricated foot orthoses vs shoes

Prefabricated foot orthoses showed no clear difference in pain(measured as proportion with pain) compared with shoes (low certainty).

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  RR 0.94 [0.76, 1.16]
  Studies not reported
  Low

Prefabricated foot orthoses vs shoes

The review found no eligible studies for this question.

• Foot orthoses for treating paediatric flat feet 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High dental-caries prevalence vs Not applicable

The review reported higher OHRQoL in the low than high dental-caries-prevalence category.

• Association between oral health-related quality of life and structural determinants of health among elderly… 2025 All outcomes

  Baseline for longitudinal studies · Community · High dental-caries prevalence
  71.40 [64.16, 78.63]
  Studies not reported
  GRADE not reported

Mandibular third molar present vs Mandibular third molar absent

In the mandible, presence of the third molar increases odds of spontaneous space closure (OR 2.28; low certainty).

• Spontaneous space closure after extraction of permanent first molars in children and adolescents: a systematic review… 2024 All outcomes

  Until eruption of the permanent second molar (median follow-up 4.0 years) · University clinics and hospitals in 8 countries (children/adolescents <18 years) · Mandible
  OR 2.28 [1.67, 3.09]
  4 studies · 467 participants
  Low

Endolymphatic sac decompression vs placebo (sham surgery)

It is very uncertain whether endolymphatic sac decompression changes improvement in vertigo (complete resolution) at 6 to ≤ 12 months (12… compared with placebo (sham surgery) (very low certainty).

• Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
  RR 1.3 [0.86, 1.96]
  1 study · 30 participants
  Very low

Endolymphatic sac decompression vs placebo (sham surgery)

• Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Endolymphatic sac decompression vs placebo (sham surgery)

The review found no eligible studies for this question.

• Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Low periodontal-disease prevalence vs Not applicable

No statistically significant difference in OHRQoL was reported by periodontal-disease prevalence.

• Association between oral health-related quality of life and structural determinants of health among elderly… 2025 All outcomes

  Baseline for longitudinal studies · Community · Low periodontal-disease prevalence
  There were no statistically significant differences reported in the OHRQoL sum scores based on periodontal disease prevalence.
  Studies not reported
  GRADE not reported

Genetically predicted periodontitis vs Without periodontitis (lower genetic liability)

Genetically predicted periodontitis was associated with modestly higher odds of lacunar stroke (OR 1.24); ungraded MR, though the FDR-adjusted P was 0.064 for the primary IVW-FE method (ML-adjusted P 0.037).

• The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study. 2025 All outcomes

  Genetic epidemiology (European-ancestry GWAS summary data)
  OR 1.24 [1.03, 1.49]
  Studies not reported
  GRADE not reported

High periodontal-disease prevalence vs Not applicable

No statistically significant difference in OHRQoL was reported by periodontal-disease prevalence.

• Association between oral health-related quality of life and structural determinants of health among elderly… 2025 All outcomes

  Baseline for longitudinal studies · Community · High periodontal-disease prevalence
  There were no statistically significant differences reported in the OHRQoL sum scores based on periodontal disease prevalence.
  Studies not reported
  GRADE not reported

Genetically predicted DMFS (dental caries) vs Without dental caries (lower genetic liability)

Genetically predicted dental caries showed no significant causal association with lacunar stroke (ungraded MR).

• The contribution of oral infectious diseases in lacunar stroke based on meta-analysis and Mendelian randomization study. 2025 All outcomes

  Genetic epidemiology (European-ancestry GWAS summary data)
  OR 0.92 [0.69, 1.23]
  Studies not reported
  GRADE not reported

Hall technique vs Conventional restoration

The reported estimate for treatment discomfort with the Hall Technique versus conventional restorations was inconclusive (ungraded).

• Minimal intervention dentistry for managing carious lesions into dentine in primary teeth: an umbrella review. 2022 All outcomes

  During treatment
  RR 1.67 [0.65, 4.25]
  2 studies
  GRADE not reported

Adhesive precoated (APC) flash-free brackets (minimal excess adhesive) vs Conventional ceramic brackets

Adhesive precoated flash-free brackets showed no demineralization difference, with certainty not graded.

• Can Orthodontic Adhesive Systems Inhibit the Formation and Development of White Spot Lesions During Fixed Orthodontic… 2024 All outcomes

  Baseline, 1 month, and 6 months after bonding · Fixed orthodontic treatment
  Intergroup evaluation showed that there were no statistically significant differences in demineralization measurements between all sides of the conventional and flash-free brackets at all the time intervals (p >0.05).
  1 study · 30 participants
  GRADE not reported

Gentamicin‐impregnated collagen sponge vs no dressing

It is very uncertain whether gentamicin‐impregnated collagen sponge changes time to wound healing (days) compared with no dressing (very low certainty).

• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Very low

Gentamicin‐impregnated collagen sponge vs no dressing

The review found no eligible studies for this question.

• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Dressings and topical agents for the management of open wounds after surgical treatment for sacrococcygeal pilonidal… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found