Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,123 questions · 2,188 findings · 243 reviews

No studies found 493 · 22.5%GRADE not reported 160 · 7.3%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.6%High 97 · 4.4%

Impregnated catheters vs antiseptic‐coated catheter

Symptomatic CAUTI: without microbiological evidence ‐ antibiotic versus silver alloy · Patients with an indwelling urethral catheter of short‐term duration

Antimicrobial‐impregnated catheter showed no clear difference in symptomatic CAUTI: without microbiological evidence ‐ antibiotic… compared with antiseptic‐coated catheter (moderate certainty).

1 finding from 1 review

Impregnated catheters vs antiseptic‐coated catheter

Symptomatic CAUTI: with microbiological evidence ‐ antibiotic versus silver alloy · Patients with an indwelling urethral catheter of short‐term duration

Antimicrobial‐impregnated catheter leads to lower symptomatic CAUTI: with microbiological evidence ‐ antibiotic versus… compared with antiseptic‐coated catheter (high certainty).

1 finding from 1 review

Oral corticosteroids vs placebo or NSAID

Proportion of patients with resolution or improved symptoms at days 3 to 7 · patients with acute sinusitis

Oral corticosteroids may leads to higher proportion of patients with resolution or improved symptoms at days… compared with placebo or NSAID (low certainty).

1 finding from 1 review

Oral corticosteroids vs placebo or NSAID

Proportion of patients with resolution or improved symptoms at days 4 to 14 ‐ Co‐treatment with antibiotics · patients with acute sinusitis

Oral corticosteroids may leads to higher proportion of patients with resolution or improved symptoms at days… compared with placebo or NSAID (low certainty).

1 finding from 1 review

Intervention not reported

Antibiotic use · patients with common cold

The intervention may leads to lower antibiotic use (low certainty).

1 finding from 1 review

Intervention not reported

Serum concentrations ‐ aminoglycoside antibiotics: peak concentration · patients with leading serum concentrations within therapeutic range
1 finding from 1 review

Intervention not reported

Aminoglycoside antibiotics ‐ nephrotoxicity · patients with leading to fewer clinical adverse events

The intervention showed no clear difference in aminoglycoside antibiotics ‐ nephrotoxicity (low certainty).

1 finding from 1 review

Intervention not reported

Proportion of participants within therapeutic range ‐ aminoglycoside antibiotics: % of participants with peak concentrations adequate after 2 days · patients with leading serum concentrations within therapeutic range

The intervention probably leads to higher proportion of participants within therapeutic range ‐ aminoglycoside… (moderate certainty).

1 finding from 1 review

Long‐acting beta2‐agonists vs placebo

Moderate exacerbations (course of antibiotics or oral steroids) · patients with chronic obstructive pulmonary disease

Long‐acting beta2‐agonists probably leads to lower moderate exacerbations (course of antibiotics or oral steroids) compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Utilisation of research (Thailand) (for six obstetric practices: social support during labour, magnesium sulphate for eclampsia, corticosteroids to women with preterm birth, selective episiotomy, antibiotic use at caesarean section and vacuum extr... · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review

Intervention not reported

Utilisation of research (Mexico) (for six obstetric practices: social support during labour, magnesium sulphate for eclampsia, corticosteroids to women with preterm birth, selective episiotomy, antibiotic use at caesarean section and vacuum extrac... · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review

Intervention not reported

Utilisation of research (4 obstetric practices: use of polyglycolic acid sutures, ventouse for instrumental delivery, prophylactic antibiotics in caesarean section, and prophylactic corticosteroids in preterm deliveries).2 · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review