Cochrane · systematic review · CD007913
Primary prophylactic colony‐stimulating factors for the prevention of chemotherapy‐induced febrile neutropenia in breast cancer patients
Renner, P, Milazzo, S, Liu, JP, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
Breast CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 6 · 60%Moderate 4 · 40%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Prevention of chemotherapy‐induced FN in breast cancer patients ‐ primary outcomes
Population: breast cancer patients undergoing chemotherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Febrile neutropenia Rates of patients | RR 0.27 [0.11, 0.7] | 6 studies · 2073 participants | Moderate Downgraded: risk of bias |
Early mortality Rates of patients | RR 0.32 [0.13, 0.77] | 8 studies · 2143 participants | Low Downgraded: risk of bias, imprecision |
Infection‐related mortality Rates of patients | RR 0.14 [0.02, 1.29] | 8 studies · 2143 participants | Low Downgraded: risk of bias |
Prevention of chemotherapy‐induced FN in breast cancer patients ‐ secondary outcomes
Population: breast cancer patients undergoing chemotherapy
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Severe neutropenia (WHO grade IV) Rates of patients | RR 0.44 [0.17, 1.18] | 4 studies · 712 participants | Moderate Downgraded: risk of bias |
Infections Rates of patients | RR 0.86 [0.72, 1.02] | 3 studies · 210 participants | Low Downgraded: risk of bias, imprecision |
Hospitalization Rates of patients | RR 0.14 [0.06, 0.3] | 4 studies · 1149 participants | Low Downgraded: risk of bias |
Antibiotics (i.v.) Rates of patients | RR 0.35 [0.22, 0.55] | 4 studies · 1568 participants | Low Downgraded: risk of bias |
Chemotherapy Rates of patients who received the planned chemotherapy doses at scheduled times and doses | RR 1.05 [0.97, 1.13] | 4 studies · 1588 participants | Low Downgraded: risk of bias |
Bone pain Rates of patients | RR 5.88 [2.54, 13.6] | 3 studies · 388 participants | Moderate Downgraded: risk of bias, imprecision |
Injection‐site reaction Rates of patients | RR 3.59 [2.33, 5.53] | 2 studies · 262 participants | Moderate Downgraded: risk of bias, imprecision |