Search review questions

Caries experience (mean DMFS) · European adolescents aged 12–19 years · Region: Scandinavian

Sensitivity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · Analysis 1: fully within-person comparison (studies evaluating >=3 index tests)

Early childhood caries (ECC) - association at lead SNP rs7325099 (13:28104496; nearest gene(s) LNX2, POLR1D, RPL21) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), rs7325099 (13:28104496); effect/non-effect allele A/C; MAF 0.50; direction across 5 cohorts ++?++

Dental caries prevalence (DMFT/dmft/DMFS/dmfs > 0) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point)

Enamel caries proportion of total caries experience · European adolescents aged 12–19 years · Age group: 16–19 years

Caries arrest · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · Pooled across follow-up evaluations (1-36 months)

Overweight/obesity risk · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western… · Follow-up to 24 months, BLISS; randomized controlled trials

Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy) · 2 years, RMGIC + composite resin (modified open-sandwich) arm

Contribution to total daily fluoride intake · Children · Medium fluoride in water (0.52-0.77 mg/L)

Mean DMFT score · Children aged 12 years (plus or minus one year) in Africa · Overall, urban/rural-status analysis

Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Crown retention · Children with primary (deciduous) teeth requiring full-coverage crown restoration · 6 months

Caries experience - mean dfs (descriptive), primary dentition · CL/P vs no CL/P; Table 4 (1 group/1 study, Dahllof 1989)

Primary maternal education prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries · Primary education

Caries prevalence · European adolescents aged 12–19 years · Publication year: ≥ 2010

Dental caries measured by net increment in DMFT scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer), Age 5-8 years

Difference in summary specificity (NMA, Analysis 2) · Imaging vs Transillumination

Specificity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · Analysis 2: network meta-analysis (all studies evaluating >=2 index tests)

Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years · 12-30 months

Dental caries prevalence (DMFT/dmft/DMFS/dmfs > 0) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point), Primary dentition (dmft > 0)

Overweight and obesity · Healthy children aged 6–24 months in Western industrialized countries · 15–20 months, observational

Accuracy advantage in test case 2 · Dental images of human beings · Patil et al., 2019

Restoration failure · Children with carious primary teeth · 1 year, Class II

Oral hairy leukoplakia (WHO clinical stage 3) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point)

Caries arrest · Children with dentine carious lesions (ICDAS 4-5) in primary teeth · 18-30 months, 38% SDF vs 5% NaF varnish/water (Trieu et al. 2019 meta-analysis)

Sensitivity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · Analysis 1: fully within-person comparison (studies evaluating >=3 index tests)

Dental caries measured by DMFS scores · Primary school children (aged 3-16 years) attending primary school in low- and middle-income countries (LMICs) · Post-intervention; follow-up varied across studies (interventions ranged from <2 years to >=2 years and longer)

Caries prevalence · 12-year-old children (permanent dentition) in Africa · Data collection period: 2010-2014

Difference in summary specificity (NMA, Analysis 2) · Electrical conductance vs Transillumination

Development of >=1 new carious lesion (caries incidence) · Children with sound primary molars, aged 2-4 years (municipal dental clinics or hospital paediatric clinics, Denmark) · 24-36 months

Contribution to total daily fluoride intake · Children · Poor fluoride in water (<0.3 mg/L)

Pain during procedure · Children (3-13 years) with dentine caries in primary teeth, no pulpal involvement · During procedure

Patient discomfort during treatment (anxiety scale) · Children (age 1-10 years) with active cavitated dentin caries lesions in primary molars · During/after the treatment procedure

Angular cheilitis (WHO clinical stage 2) · Children and adolescents (<18 years) · Cross-sectional (case-control; single time point)

Mean annual restoration failure rate · Children (2-9 years) with caries in posterior primary teeth · First 3 years, Multi-surface

Sensitivity for detecting enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies) · Analysis 2: network meta-analysis (all studies evaluating >=2 index tests)

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Setting: Rural

Difference in summary specificity (NMA, Analysis 2) · Fluorescence vs Imaging

Restoration survival · Children with occlusoproximal caries in primary teeth · 2–3 years

Clinical and radiographic success rate (>=6 months) · Human permanent teeth with irreversible pulpitis (symptomatic and asymptomatic) due to carious pulp exposure · >=6 months (follow-up 6 to 73.6 months)

Color change · Patients with post-orthodontic white spot lesions and permanent dentition · 6 months

Caries prevalence · European adolescents aged 17 years · Exact age

Good brushing habits prevalence (among children with caries) · Children with dental caries (deciduous and/or permanent dentition) in low- and middle-income countries

Caries experience (mean DMFS) · European adolescents aged 12–19 years · Publication year: < 2010

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: Uganda

Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years · 12-60 months (Welbury 5 years; Kilpatrick 1.5 years mean)

Treatment failure (annual failure rate) by cavity class · Children with carious primary teeth restored in Class-I versus Class-II cavities, no pulp therapy · 12-48 months, Cavity class (Class-I vs Class-II)

Caries prevalence · European adolescents aged 12–19 years · Age group: 16–19 years

Caries severity (mean DMFT) · 12-year-old children (permanent dentition) in Africa · Country: Zimbabwe

Early childhood caries (ECC) - association with genetically predicted expression of LACC1 (chr13q14.11) · Children up to age 5-6 years (European / European non-Hispanic ancestry); 843 ECC-affected vs 2124 unaffected across 5… · Cross-sectional (ECC ascertained at the last dental exam before age 6), LACC1 (chr13q14.11); 48 (4) tissues; suggestive (p < 1.0x10-4) ; flagged possible false positive