Findings

What do systematic reviews say?

164 questions · 166 findings · 28 reviews · Headline outcomes only

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No studies found 52 · 31.3%GRADE not reported 17 · 10.2%Very low 41 · 24.7%Low 43 · 25.9%Moderate 12 · 7.2%High 1 · 0.6%

Systemic aminocaproic acid vs placebo

Final visual acuity 20/40 or better at resolution of hyphema · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in final visual acuity 20/40 or better at resolution of hyphema compared with placebo (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.05 [0.93, 1.18]
2 studies · 143 participants
Low

Topical aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.87 [0.47, 1.6]
1 study · 51 participants
Low

Topical aminocaproic acid vs placebo

Medium‐term visual acuity 20/40 or better > 2 weeks and ≤ 2 months after treatment · people with traumatic hyphema

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings table ‐ Pseudophakia vs aphakia

Visual acuity · children younger than two years of age with bilateral congenital cataracts

1 finding from 1 review

Surgical interventions for bilateral congenital cataract in children aged two years and under 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 54 participants
Very low

Summary of findings table ‐ Pseudophakia vs aphakia

Visual axis opacification · children younger than two years of age with bilateral congenital cataracts

It is very uncertain whether summary of findings table ‐ Pseudophakia changes visual axis opacification compared with aphakia (very low certainty).

1 finding from 1 review

Surgical interventions for bilateral congenital cataract in children aged two years and under 2022 · Cochrane Headline outcomes only
RR 1.29 [0.23, 7.13]
1 study · 54 participants
Very low

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Visual acuity · infantile nystagmus syndrome

1 finding from 1 review

Surgical interventions for infantile nystagmus syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 10 participants
Very low

Summary of Findings Table ‐ Large retro‐equatorial recession of horizontal rectus muscle of 9 mm on the medial rectus and 12 mm on the lateral rectus vs simple tenotomy and resuturing of the 4 horizontal rectus muscles

Change in visual recognition times ‐ not reported · infantile nystagmus syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions for infantile nystagmus syndrome 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

soft non‐manipulative osteopathic treatment vs no intervention

Pain intensity (0‐10cm visual analogue scale) · people with Crohn's disease

1 finding from 1 review

Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low

Relaxation vs WAIT LIST

Pain intensity (0‐10cm visual analogue scale) · people with inflammatory bowel disease

1 finding from 1 review

Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 56 participants
Very low

Web‐based education vs standard book‐based education

Pain intensity (0‐10cm visual analogue scale) · people with inflammatory bowel disease

1 finding from 1 review

Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 60 participants
Very low

Low FODMAP diet vs sham diet

Adverse event ‐ pain, visual analogue scale · people with inflammatory bowel disease

1 finding from 1 review

Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 82 participants
Very low

tDCS vs sham stimulation

Pain intensity (0‐10cm visual analogue scale) · people with inflammatory bowel disease

1 finding from 1 review

Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Low FODMAP diet vs sham diet

Pain intensity (0‐10cm visual analogue scale) · people with inflammatory bowel disease

1 finding from 1 review

Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Very low

Low FODMAP diet vs sham diet

Pain intensity (0‐10cm visual analogue scale) · UC patients

1 finding from 1 review

Interventions for the management of abdominal pain in ulcerative colitis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 26 participants
Very low

Ursodeoxycholic acid vs placebo

Pruritus · pregnant women with intrahepatic cholestasis

1 finding from 1 review

Pharmacological interventions for treating intrahepatic cholestasis of pregnancy 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 715 participants
Moderate

Any prophylaxis vs no prophylaxis

Blindness · newborn children

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing ophthalmia neonatorum 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Any prophylaxis vs no prophylaxis

Any adverse visual outcome · newborn children

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing ophthalmia neonatorum 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral magnesium vs placebo/no treatment

At least 50% reduction in pain · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes intensity of pain: 50% reduction in pain score 100‐mm visual… compared with placebo/no treatment (very low certainty).

1 finding from 1 review

Interventions for leg cramps in pregnancy 2020 · Cochrane Headline outcomes only
RR 1.43 [0.99, 2.06]
1 study · 86 participants
Very low

Oral magnesium vs placebo/no treatment

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · treating leg cramps in pregnancy

1 finding from 1 review

Interventions for leg cramps in pregnancy 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 69 participants
Low

Cognitive training vs control intervention

Visual processing post‐treatment · cognition in PDD and PD‐MCI

1 finding from 1 review

Cognitive training interventions for dementia and mild cognitive impairment in Parkinson’s disease 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 64 participants
Low