Cochrane · systematic review · CD000493
Pharmacological interventions for treating intrahepatic cholestasis of pregnancy
Walker, KF, Chappell, LC, Hague, WM, et al. · Cochrane Database of Systematic Reviews · 2020 · Cochrane Library
Pregnancy and ChildbirthAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 2 · 66.7%Low 0 · 0%Moderate 1 · 33.3%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Ursodeoxycholic acid (UDCA) versus placebo
Population: pregnant women with intrahepatic cholestasis
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pruritus score* (points out of 100 mm visual analogue scale) Ursodeoxycholic acid (UDCA) vs placebo | no estimate extracted | 2 studies · 715 participants | Moderate Downgraded: imprecision |
Stillbirth Ursodeoxycholic acid (UDCA) vs placebo | RR 0.33 [0.08, 1.37] | 6 studies · 955 participants | Very low Downgraded: risk of bias, imprecision |
Fetal distress/asphyxial events Ursodeoxycholic acid (UDCA) vs placebo | RR 0.7 [0.35, 1.4] | 6 studies · 944 participants | Very low Downgraded: risk of bias, imprecision |