Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

184 questions · 196 findings · 42 reviews · Neonatal

No studies found 32 · 16.3%GRADE not reported 2 · 1%Very low 43 · 21.9%Low 62 · 31.6%Moderate 39 · 19.9%High 18 · 9.2%

Lower vs higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth

Severe intraventricular haemorrhage · preterm infants

Lower showed no clear difference in severe intraventricular haemorrhage (grade 3 or 4) compared with higher oxygen concentrations titrated to target oxygen saturations… (low certainty).

1 finding from 1 review

Respiratory support vs no respiratory support before cord clamping

Severe intraventricular haemorrhage · preterm infants

It is very uncertain whether respiratory support changes severe intraventricular haemorrhage grade 3 or 4 compared with no respiratory support before cord clamping (very low certainty).

1 finding from 1 review

Cerebral NIRS oximetry vs no cerebral NIRS oximetry

Intraventricular haemorrhage, Papile grade 3/4 · patients with preventing morbidity and mortality in very preterm infants

It is very uncertain whether cerebral NIRS oximetry changes intraventricular haemorrhage grade III or IV compared with no cerebral NIRS oximetry (very low certainty).

1 finding from 1 review

Rescue high‐frequency jet ventilation vs conventional ventilation

Severe intraventricular haemorrhage · preterm infants with severe pulmonary dysfunction

Rescue high‐frequency jet ventilation showed no clear difference in severe intraventricular haemorrhage (grades 3 and 4) compared with conventional ventilation (low certainty).

1 finding from 1 review

Bovine lung lavage surfactant extract vs porcine minced lung surfactant extract

Severe intraventricular hemorrhage in infants who received neuroimaging · Preterm infants for treatment of RDS

It is very uncertain whether bovine lung lavage surfactant extract changes severe intraventricular hemorrhage in infants who received… compared with porcine minced lung surfactant extract (very low certainty).

1 finding from 1 review

Modified bovine minced lung surfactant extract vs porcine minced lung surfactant extract

Severe intraventricular hemorrhage in infants who received neuroimaging · Preterm infants for treatment of RDS

It is very uncertain whether modified bovine minced lung surfactant extract changes severe intraventricular hemorrhage in infants who received… compared with porcine minced lung surfactant extract (very low certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of necrotising enterocolitis stage ≥ 2 · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in risk of necrotising enterocolitis stage ≥ 2 compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Number of infants with feed interruption episodes (lasting ≥ 12 hours) · preterm infants

Summary of findings table ‐ routine monitoring may leads to higher number of infants with feed interruption episodes (lasting ≥ 12 hours) compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Risk of invasive Infection · preterm infants

Summary of findings table ‐ routine monitoring probably leads to higher risk of invasive infection compared with no routine monitoring of gastric residual (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ routine monitoring vs no routine monitoring of gastric residual

Mortality before hospital discharge · preterm infants

Summary of findings table ‐ routine monitoring showed no clear difference in all‐cause mortality before hospital discharge compared with no routine monitoring of gastric residual (low certainty).

1 finding from 1 review