Presence/absence of HSV oral lesions · Patients being treated for cancer (predominantly haematological malignancies)
Prophylactic aciclovir (oral or intravenous) showed no clear difference in presence/absence of HSV oral lesions compared with prophylactic valaciclovir (oral); GRADE not reported.
1 finding from 1 review
Cost of oral care · Patients being treated for cancer (predominantly haematological malignancies)
1 finding from 1 review
Only one trial reported on the cost of prophylaxis for HSV (Liesveld 2002). The reported mean pharmacy costs for those randomised to receive aciclovir were $1080 compared to $320 for those initially randomised to…
1 study · 30 participants
GRADE not reported
Failed Treatment · preterm infants
It is very uncertain whether prophylactic or very early CPAP changes failed treatment defined as recurrent apnoea, hypoxia, hypercarbia… compared with supportive care (very low certainty).
1 finding from 1 review
Bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency at 36 weeks postmenstrual age · preterm infants
Prophylactic or very early CPAP showed no clear difference in bronchopulmonary dysplasia at 36 weeks defined as oxygen dependency… compared with supportive care (moderate certainty).
1 finding from 1 review
Death at any time · preterm infants
Prophylactic or very early CPAP showed no clear difference in death at any time compared with supportive care (moderate certainty).
1 finding from 1 review
Death or oxygen requirement at 36 weeks' postmenstrual age · preterm infants
Prophylactic or very early CPAP showed no clear difference in combined outcome of death and bronchopulmonary dysplasia defined as… compared with supportive care (low certainty).
1 finding from 1 review
Pulmonary air leak defined as pneumothorax · preterm infants
Prophylactic or very early CPAP showed no clear difference in pulmonary air leak defined as pneumothorax compared with supportive care (low certainty).
1 finding from 1 review
Intraventricular haemorrhage, Papile grade 3/4 · preterm infants
Prophylactic or very early CPAP showed no clear difference in intraventricular haemorrhage grade 3 or 4 compared with supportive care (low certainty).
1 finding from 1 review
Neurodevelopmental disability · preterm infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Bleeding: Numbers of patients with at least one significant bleeding event · People with a haematological disorder
It is very uncertain whether prophylactic platelet transfusion changes number of participants with a significant bleeding event compared with platelet‐poor plasma (very low certainty).
1 finding from 1 review
Mortality: secondary to bleeding · People with a haematological disorder
It is very uncertain whether prophylactic platelet transfusion changes mortality: secondary to bleeding compared with platelet‐poor plasma (very low certainty).
1 finding from 1 review
Number of platelet transfusions per participant up to 30 days from study entry · People with a haematological disorder
1 finding from 1 review
FEV1 % predicted · children with cystic fibrosis
1 finding from 1 review
Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis
Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).
1 finding from 1 review
Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis
Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).
1 finding from 1 review
Need for additional antibiotic therapy · children with cystic fibrosis
Summary of findings ‐ Prophylactic showed no clear difference in number of people needing additional antibiotics compared with 'as required' anti‐staphylococcal antibiotics (low certainty).
1 finding from 1 review
Weight (z score) · children with cystic fibrosis
1 finding from 1 review
Acquisition of multiply‐resistant S aureus · children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events of treatment · children with cystic fibrosis
1 finding from 1 review
Mortality ( · adult participants (> 16 years of age) undergoing intestinal resection due to Crohn's disease
1 finding from 1 review