Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

199 questions · 208 findings · 27 reviews · Drugs and Alcohol

No studies found 5 · 2.4%GRADE not reported 6 · 2.9%Very low 45 · 21.6%Low 79 · 38%Moderate 59 · 28.4%High 14 · 6.7%

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: clonidine versus buprenorphine, inpatient setting · management of opium withdrawal

It is very uncertain whether pharmacological detoxification treatment changes completion of treatment: clonidine versus buprenorphine, inpatient… compared with other pharmacological detoxification treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Point‐prevalence abstinence rates at short‐term · adults with cannabis use disorder or frequent cannabis use

The intervention may leads to higher point‐prevalence abstinence rates at short‐term (low certainty).

1 finding from 1 review

Intervention not reported

Number commencing naltrexone maintenance treatment ‐ Buprenorphine comparison · patients with opioid withdrawal

The intervention probably leads to higher number commencing naltrexone maintenance treatment ‐ Buprenorphine… (moderate certainty).

1 finding from 1 review

Intervention not reported

Retained in naltrexone maintenance treatment or abstinent at 12 weeks ‐ Buprenorphine comparison · patients with opioid withdrawal

The intervention showed no clear difference in retained in naltrexone maintenance treatment or abstinent at 12… (moderate certainty).

1 finding from 1 review

Psychosocial interventions vs treatment

Number of continuously abstinent women ‐ total · stopping or reducing alcohol consumption during pregnancy

Summary of findings table ‐ Any psychosocial intervention may leads to higher number of continuously abstinent women ‐ total compared with treatment (low certainty).

1 finding from 1 review

Psychosocial interventions vs treatment

Number of women who completed treatment ‐ total · stopping or reducing alcohol consumption during pregnancy

Summary of findings table ‐ Any psychosocial intervention showed no clear difference in number of women who completed treatment ‐ total compared with treatment (moderate certainty).

1 finding from 1 review

Integrated CBT vs Twelve Step Facilitation

Percent of days abstinent · co‐occurring depression and substance use disorders
2 findings from 1 review