Pulp necrosis · Vital teeth
The pooled incidence with radiographic assessment was 4.95%.
2 findings from 1 review
Proportion 4.95 [2.43, 8.29]
5 studies · 1853 participants
GRADE not reported
Proportion 5.66 [3.71, 7.99]
24 studies · 6581 participants
GRADE not reported
Xerostomia (dry mouth relief) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Johnson 1993: positive response (>25 mm change in VAS score) in 25% of participants on placebo, 51% on pilocarpine 5 mg tds, 47% on pilocarpine 10 mg tds. LeVeque 1993: positive response in 7% on placebo vs 42% on…
2 studies · 278 participants
GRADE not reported
Other oral symptoms (oral discomfort, dysphonia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Both studies assessed oral discomfort and dysphonia (Johnson 1993; LeVeque 1993); pilocarpine reported to improve associated symptoms of salivary gland dysfunction (oral discomfort, dysphonia). No pooled data.
2 studies · 278 participants
GRADE not reported
Salivary flow rate · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Adverse effects (side effects; treatment withdrawals) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Johnson 1993 (5 mg tds): sweating 37%, headache 15%, urinary frequency 14%, vasodilatation 12%, dizziness 10%, dyspepsia 10%, nausea 8%, asthenia 8%, diarrhoea 5%; 6% withdrew at 5 mg tds and 29% at 10 mg tds. LeVeque…
2 studies · 278 participants
GRADE not reported
Other oral symptoms (dysgeusia, dysphagia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Dry mouth (xerostomia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Davies 1994 (cross-over, 20 participants): mean improvement in VAS score 22.5 mm with pilocarpine vs 15.2 mm with artificial saliva (100 mm scale). The improvement was greater with pilocarpine but was not statistically…
1 study · 20 participants
GRADE not reported
Adverse effects (side effects; treatment withdrawals) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review
Davies 1994: main side effects with pilocarpine were nausea 20%, sweating 15%, lacrimation 10%. One participant definitely withdrew because of side effects; another may have.
1 study · 20 participants
GRADE not reported
Parasympathomimetic drugs (choline esters, cholinesterase inhibitors) vs No treatment
Outcome not reported · Patients with radiation-induced salivary gland dysfunction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
A trim-and-fill sensitivity analysis pooling every exposure estimate gave an overall OR of 0.17 (95% CI 0.13-0.21) after correcting for significant publication bias (Fig. 13); this combined estimate spans heterogeneous exposures and is a publication-bias sensitivity result (ungraded).
1 finding from 1 review
Enamel/dental hard-tissue changes and e-liquid cariogenic properties (demineralization, colour change, pH, sugar content, metals) · Oral bacteria (streptococci), dental hard tissue (enamel/dentin) and e-liquids studied in vitro/ex vivo (with a few clinical microbiome…
In vitro evidence suggests e-liquids are often acidic and sugar-containing and can alter enamel/dentin colour and properties, supporting a plausible cariogenic effect, but findings are heterogeneous and not pooled (ungraded, narrative).
1 finding from 1 review
Periodontal parameters (all measures pooled) in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)
Pooling all periodontal measures, oral cancer patients had worse periodontal status than controls (SMD 0.95, 95% CI 0.41-1.49; very high heterogeneity, I2=96.8%); ungraded. Note this pools clinically different measures.
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs10974056 in GLIS3 (P=3.93E-08); ungraded.
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs4801882 in SIGLEC5 (P=1.71E-08); ungraded.
1 finding from 1 review
Impaired OHRQoL measured with CPQ 11-14 (quantitative synthesis / meta-analysis) · Adolescents (10-19 years)
Malocclusion (DAI) probably increases the prevalence of impaired OHRQoL (CPQ 11-14) by about 15% in adolescents (RR/PR 1.15, 95% CI 1.12-1.18; moderate certainty).
1 finding from 1 review
Remineralization / reduction in lesion severity (change in QLF, laser fluorescence, or lesion area) · People or specimens with white spot lesions or early caries lesions
The NMA estimated an SMD of -0.78 for P11-4 + fluoride varnish versus CPP-ACP (95% CI -1.33 to -0.28).
1 finding from 1 review
SMD -0.78 [-1.33, -0.24]
Studies not reported
GRADE not reported
Intervention not reported
Calcific metamorphosis (adverse event)
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Unmet dental treatment need · Children aged 1-18 years
Narrative reports from 6 studies suggested greater unmet dental treatment need in children with learning disabilities (5 of 6 studies), but no quantitative data were available (certainty not graded).
1 finding from 1 review
Caries experience (mean DMFT) · Adults aged 19-60 years
Studies of older adults (mean age >33.4 years) had higher pooled DMFT than younger adults, but the age to DMFT meta-regression was not statistically significant; ungraded observational evidence.
5 findings from 1 review
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Caries experience (mean DMFT) · Adults aged 19-60 years
Populations with a higher proportion of people with low socioeconomic status had higher caries experience (pooled DMFT 15.99 vs 5.50), and meta-regression associated low SES with higher DMFT (about 10.35 more DMFT per unit; p=0.050); ungraded observational evidence.
5 findings from 1 review
Show 2 more findings