Number of participants referred for surgical exposure of the PDC · Young people aged 9 to 14 years diagnosed with one or both palatally displaced permanent maxillary canines (PDC)
It is very uncertain whether extraction of the primary (baby) canine (single primary tooth… changes number of participants referred for surgical exposure of the PDC compared with no extraction (non-intervention control) (very low certainty).
1 finding from 1 review
Other measures of exposure · healthcare staff who handle infusional hazardous drugs
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Severity of PTSD symptoms ‐ Clinician‐rated · Adults with PTSD for at least 3 months
1 finding from 1 review
Leaving the study early · Adults with PTSD for at least 3 months
It is very uncertain whether trauma‐focused CBT/Exposure therapy changes leaving the study early for any reason compared with waitlist/Usual Care (very low certainty).
1 finding from 1 review
Severity of PTSD symptoms ‐ Clinician‐rated · Adults with PTSD for at least 3 months
1 finding from 1 review
Leaving the study early · Adults with PTSD for at least 3 months
It is very uncertain whether trauma‐focused CBT/Exposure therapy changes leaving the study early for any reason compared with non‐TFCBT (very low certainty).
1 finding from 1 review
Severity of PTSD symptoms ‐ Clinician‐rated · Adults with PTSD for at least 3 months
1 finding from 1 review
Leaving the study early · Adults with PTSD for at least 3 months
It is very uncertain whether trauma‐focused CBT/Exposure therapy changes leaving the study early for any reason compared with other therapies (very low certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to gonadotropins for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to gonadotropins for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to GnRH analogues for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).
1 finding from 1 review
Salivary IL-6 level (pg/mL) · Children and young adults (3-25 years)
Salivary IL-6 levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 11.60 pg/mL, 95% CI 6.27 to 16.94; 11 studies); ungraded.
1 finding from 1 review
Salivary IL-8 level (pg/mL) · Children and young adults (3-25 years)
Salivary IL-8 levels are higher in children and young adults with active dental caries than in controls but the difference is not statistically significant (SMD 57.20 pg/mL, 95% CI -18.60 to 133.00; 7 studies); ungraded.
1 finding from 1 review
TNF-α level · Children and young adults (3-25 years)
Salivary TNF-α levels are significantly higher in children and young adults with active dental caries than in caries-free or mild-caries controls (SMD 14.81 pg/mL, 95% CI 4.76 to 24.86; 7 studies); ungraded.
1 finding from 1 review
Repetition of SH at post‐intervention · self‐harm in adults
Comparison 2.4: DBT prolonged exposure protocol showed no clear difference in repetition of SH at post‐intervention compared with TAU or another comparator (moderate certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to clomiphene citrate for subfertility changes endometrial cancer compared with untreated subfertile women and endometrial cancer risk (very low certainty).
1 finding from 1 review
Endometrial cancer · Women treated with ovary‐stimulating drugs for subfertility
It is very uncertain whether exposure to clomiphene citrate for subfertility changes endometrial cancer compared with general population and endometrial cancer risk (very low certainty).
1 finding from 1 review
Food choice · Children and adolescents (general population, aged under 20 years)
In crossover studies with binary outcomes, food marketing had no clear association with food choice (OR 3.45, 95% CI 0.97 to 12.43; ungraded).
1 finding from 1 review
OR 3.45 [0.97, 12.43]
3 studies
GRADE not reported
Food purchasing · Children and adolescents (general population, aged under 20 years)
Across five studies, 40% showed any association of potential public health harm for food purchasing (very low certainty).
1 finding from 1 review
Dental caries · Children and adolescents (general population, aged under 20 years)
Across two studies, 50% showed any association of potential public health harm for dental caries (very low certainty).
1 finding from 1 review