Cochrane · systematic review · CD010931
Risk of endometrial cancer in women treated with ovary‐stimulating drugs for subfertility
Skalkidou, A, Sergentanis, TN, Gialamas, SP, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecological, Neuro-oncology and Orphan CancerAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 9 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Exposure to any ovary‐stimulating drugs for subfertility compared to untreated subfertile women and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to any ovary‐stimulating drugs for subfertility vs untreated subfertile women and endometrial cancer risk | RR 0.96 [0.67, 1.37] | 6 studies · 156774 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to any ovary‐stimulating drugs for subfertility compared to general population and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to any ovary‐stimulating drugs for subfertility vs general population and endometrial cancer risk | RR 1.75 [1.18, 2.61] | 15 studies · 1762829 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Exposure to clomiphene citrate for subfertility compared to untreated subfertile women and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to clomiphene citrate for subfertility vs untreated subfertile women and endometrial cancer risk | RR 1.32 [1.01, 1.71] | 5 studies · 92849 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to clomiphene citrate for subfertility compared to general population and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to clomiphene citrate for subfertility vs general population and endometrial cancer risk | RR 1.87 [1, 3.48] | 4 studies · 19614 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to gonadotropins for subfertility compared to untreated subfertile women and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to gonadotropins for subfertility vs untreated subfertile women and endometrial cancer risk | RR 1.55 [1.03, 2.34] | 4 studies · 17769 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to gonadotropins for subfertility compared to general population and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to gonadotropins for subfertility vs general population and endometrial cancer risk | RR 2.12 [0.79, 5.64] | 2 studies · 1595 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to clomiphene citrate and gonadotropins for subfertility compared to untreated subfertile women and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to clomiphene citrate and gonadotropins for subfertility vs untreated subfertile women and endometrial cancer risk | RR 1.18 [0.57, 2.44] | 2 studies · 6345 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to clomiphene citrate and gonadotropins for subfertility compared to general population and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to clomiphene citrate and gonadotropins for subfertility vs general population and endometrial cancer risk | RR 2.99 [1.53, 5.86] | 3 studies · 7789 participants | Very low Downgraded: risk of bias, imprecision |
Exposure to GnRH analogues for subfertility compared to untreated subfertile women and endometrial cancer risk
Population: Women treated with ovary‐stimulating drugs for subfertility
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Endometrial cancer Exposure to GnRH analogues for subfertility vs untreated subfertile women and endometrial cancer risk | RR 1.21 [0.65, 2.27] | 2 studies · 42558 participants | Very low Downgraded: risk of bias, imprecision |