Findings

What do systematic reviews say?

279 questions · 283 findings · 23 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 96 · 33.9%GRADE not reported 1 · 0.4%Very low 47 · 16.6%Low 62 · 21.9%Moderate 62 · 21.9%High 15 · 5.3%

Intervention not reported

Antibiotic resistance patterns following treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Once‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ PEP vs oscillating PEP

Number of respiratory exacerbations: requiring either IV antibiotics or hospitalisation · adults and children with CF

1 finding from 1 review

Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Moderate

Intervention not reported

Respiratory outcomes: Antibiotic days per patient in past 3 months · children and adults with CF

1 finding from 1 review

Vitamin A and beta (β)‐carotene supplementation for cystic fibrosis 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Intervention not reported

Number of days on antibiotics for acute exacerbations · infants and young children with cystic fibrosis

The intervention showed no clear difference in number of days on antibiotics for acute exacerbations (moderate certainty).

1 finding from 1 review

Standard (head‐down tilt) versus modified (without head‐down tilt) postural drainage in infants and young children… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Moderate

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Adverse events during treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 131 participants
Low

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Quality of life · adults and children with cystic fibrosis

1 finding from 1 review

Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
GRADE not reported

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Change in sputum P aeruginosa density at end of treatment (cfu/g) · adults and children with cystic fibrosis

Summary of findings: single showed no clear difference in change in sputum P aeruginosa density at end of treatment (cfu/g) compared with combination intravenous anti‐pseudomonal antibiotic therapy (moderate certainty).

2 findings from 1 review

Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 76 participants
Moderate
Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Need for extra treatment · adults and children with cystic fibrosis

The review found no eligible studies for this question.

2 findings from 1 review

Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

Quality of life Â · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: Single vs combination intravenous anti‐pseudomonal antibiotic therapy

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Single versus combination intravenous anti‐pseudomonal antibiotic therapy for people with cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

FEV1 % predicted · children with cystic fibrosis

1 finding from 1 review

Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 119 participants
Low

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of S aureus (sensitive strains) · children with cystic fibrosis

Summary of findings ‐ Prophylactic may leads to lower number of people with one or more isolates of S aureus (sensitive… compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis 2020 · Cochrane Headline outcomes only
OR 0.21 [0.13, 0.35]
3 studies · 315 participants
Low

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Number of people with one or more isolates of P aeruginosa · children with cystic fibrosis

Summary of findings ‐ Prophylactic showed no clear difference in number of people with one or more isolates of P aeruginosa compared with 'as required' anti‐staphylococcal antibiotics (low certainty).

1 finding from 1 review

Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis 2020 · Cochrane Headline outcomes only
OR 0.74 [0.45, 1.23]
3 studies · 312 participants
Low

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Weight (z score) · children with cystic fibrosis

1 finding from 1 review

Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 140 participants
Low

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Acquisition of multiply‐resistant S aureus · children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Prophylactic vs 'as required' anti‐staphylococcal antibiotics

Adverse events of treatment · children with cystic fibrosis

1 finding from 1 review

Prophylactic anti‐staphylococcal antibiotics for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 119 participants
Low

Single vs combination IV antibiotics

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

1 finding from 1 review

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 265 participants
Low

Single vs combination IV antibiotics

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

1 finding from 1 review

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 146 participants
Low

Single vs combination IV antibiotics

Time to next exacerbation · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

1 finding from 1 review

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Low

Single vs combination IV antibiotics

Quality of life · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found