Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

633 questions · 668 findings · 122 reviews · Headline outcomes only

No studies found 144 · 21.6%GRADE not reported 27 · 4%Very low 154 · 23.1%Low 194 · 29%Moderate 119 · 17.8%High 30 · 4.5%

Macrolide+tetracycline vs macrolides

All‐cause serious adverse events 60 weeks (end of study) · patients with chronic obstructive pulmonary disease

It is very uncertain whether macrolide+tetracycline changes all‐cause serious adverse events 60 weeks (end of study) compared with macrolide (very low certainty).

1 finding from 1 review

Macrolide+tetracycline vs macrolides

Number of people experiencing one or more exacerbations, Drug resistance/microbial sensitivity (as reported by trialists), including emergence of atypical bacteria, Number of participants colonised with Pseudomonas aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Cyanoacrylate vs band ligation

Mortality Total of deaths and the end of · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate changes mortality Total of deaths and the end of compared with band ligation (very low certainty).

1 finding from 1 review

Cyanoacrylate vs alcohol

Re‐bleeding Re‐bleeding after intervention · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate changes re‐bleeding Re‐bleeding after intervention compared with alcohol (very low certainty).

1 finding from 1 review

Cyanoacrylate vs alcohol

Control of bleeding Success in control the active variceal bleeding · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate changes control of bleeding Success in controlling the active variceal… compared with alcohol (very low certainty).

1 finding from 1 review

Cyanoacrylate vs band ligation

Failure of intervention Continuous variceal bleeding after intervention · acute bleeding gastric varices in people with portal hypertension

It is very uncertain whether cyanoacrylate changes failure of intervention Continuous variceal bleeding after… compared with band ligation (very low certainty).

1 finding from 1 review