Cochrane · systematic review · CD010180
Endoscopic injection of cyanoacrylate glue versus other endoscopic procedures for acute bleeding gastric varices in people with portal hypertension
Ríos Castellanos, E, Seron, P, Gisbert, JP, et al. · Cochrane Database of Systematic Reviews · 2015 · Cochrane Library
Hepato-BiliaryAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
16
current version
GRADE rated
16
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 15 · 93.8%Low 1 · 6.3%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Cyanoacrylate versus band ligation for acute bleeding gastric varices in people with portal hypertension
Population: acute bleeding gastric varices in people with portal hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Total of deaths and the end of Cyanoacrylate vs band ligation | RR 0.83 [0.52, 1.31] | 4 studies · 365 participants | Very low Downgraded: risk of bias, imprecision, indirectness |
Failure of intervention Continuous variceal bleeding after intervention Cyanoacrylate vs band ligation | RR 1.13 [0.23, 5.69] | 4 studies · 264 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Re‐bleeding Re‐bleeding after the bleeding was controlled in the first intervention Cyanoacrylate vs band ligation | RR 0.6 [0.41, 0.88] | 4 studies · 360 participants | Low Downgraded: risk of bias, indirectness |
Complications (general) Number of total complications Cyanoacrylate vs band ligation | RR 2.81 [0.69, 11.49] | 3 studies · 307 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Control of bleeding Success in control variceal bleeding Cyanoacrylate vs band ligation | RR 1.07 [0.9, 1.27] | 4 studies · 264 participants | Very low Downgraded: risk of bias, imprecision, inconsistency, indirectness |
Cyanoacrylate 1 mL versus cyanoacrylate 0.5 mL for acute bleeding gastric varices in people with portal hypertension
Population: acute bleeding gastric varices in people with portal hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total mortality Total deaths and the end of Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL | RR 1.02 [0.65, 1.6] | 1 study · 91 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
day ‐ mortality Mortality due to bleeding Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL | RR 1.07 [0.41, 2.8] | 1 study · 91 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Failure of intervention Continuous bleeding after intervention Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL | RR 1.07 [0.56, 2.05] | 1 study · 91 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Complications (fever) Presence of fever Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL | RR 0.56 [0.32, 0.98] | 1 study · 91 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Re‐bleeding Bleeding after initial success in the intervention Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL | RR 1.3 [0.73, 2.31] | 1 study · 91 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Control of bleeding Success in control the active variceal bleeding Cyanoacrylate 1 mL vs cyanoacrylate 0.5 mL | RR 1.04 [0.78, 1.38] | 1 study · 25 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Cyanoacrylate versus alcohol for acute bleeding gastric varices in people with portal hypertension
Population: acute bleeding gastric varices in people with portal hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Mortality Total deaths at 30 days Cyanoacrylate vs alcohol | RR 0.43 [0.09, 2.04] | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Failure of intervention Cyanoacrylate vs alcohol | RR 0.36 [0.09, 1.35] | 1 study · 17 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Complications (fever) Presence of fever Cyanoacrylate vs alcohol | RR 0.43 [0.22, 0.8] | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Re‐bleeding Re‐bleeding after intervention Cyanoacrylate vs alcohol | RR 0.85 [0.3, 2.45] | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |
Control of bleeding Success in controlling the active variceal bleeding Cyanoacrylate vs alcohol | RR 1.79 [1.13, 2.84] | 1 study · 37 participants | Very low Downgraded: risk of bias, imprecision, indirectness, publication bias |