Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

157 questions · 158 findings · 44 reviews · Headline outcomes only

No studies found 25 · 15.8%GRADE not reported 7 · 4.4%Very low 40 · 25.3%Low 50 · 31.6%Moderate 33 · 20.9%High 3 · 1.9%

Intramuscular vitamin K vs intravenous vitamin K

Intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in intraventricular hemorrhage > Grade II: 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Intramuscular vitamin K vs intravenous vitamin K

Presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM · preterm infants

Intramuscular vitamin K showed no clear difference in presence of PIVKA II at day 25 ‐ 0.2 mg IV versus 0.5 mg IM compared with intravenous vitamin K (low certainty).

1 finding from 1 review

Intervention not reported

Eyes within ± 0.5 D of target refraction · participants aged 18‐60 years with myopia ranging in severity up to 12 diopters (D)

It is very uncertain whether the intervention changes eyes within ± 0.5 D of target refraction (very low certainty).

1 finding from 1 review

Intervention not reported

Failure to achieve peak levels of at least 5 microgram/ml (measured 0.5 to one hour after administration of any dose of gentamicin) · neonates with suspected or proven sepsis

The intervention probably leads to lower failure to achieve peak levels of at least 5 microgram/ml (measured… (moderate certainty).

1 finding from 1 review