Cochrane · systematic review · CD009729
Over the counter (OTC) artificial tear drops for dry eye syndrome
Pucker, AD, Ng, SM, Nichols, JJ · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Eyes and VisionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
31
current version
GRADE rated
2
No studies
1
Included studies
NR
No studies 1 · 3.2%Ungraded 28 · 90.3%Very low 0 · 0%Low 2 · 6.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: people with dry eye
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Comparison (Intervention vs. comparator) | no estimate extracted | NR | No studies |
a) | no estimate extracted | 2 studies · 297 participants | Low Downgraded: risk of bias |
b) | no estimate extracted | 1 study · 19 participants | Ungraded |
c) | no estimate extracted | 1 study · 49 participants | Ungraded |
PEG 400 + PG + HP‐guar vs. CMC | no estimate extracted | 6 studies · 471 participants | Ungraded |
PEG 400 + PG or sodium hyaluronate vs. HPMC or CMC | no estimate extracted | 1 study · 30 participants | Ungraded |
0.4% PEG 400 + PG vs. 0.25% PEG 400 | no estimate extracted | 1 study · 22 participants | Ungraded |
0.25% PEG 400 vs.1% CMC | no estimate extracted | 1 study · 104 participants | Ungraded |
0.25% PEG 400 vs. 0.3% HPMC | no estimate extracted | 1 study · 20 participants | Ungraded |
PEG 400 vs. HP‐guar | no estimate extracted | 1 study · 40 participants | Ungraded |
0.5% CMC vs. sodium hyaluronate | no estimate extracted | 2 studies · 131 participants | Low Downgraded: risk of bias |
0.5% CMC vs. 0.3% HPMC | no estimate extracted | 3 studies · 268 participants | Ungraded |
0.5% CMC vs 1% CMC | no estimate extracted | 1 study · 103 participants | Ungraded |
lipid‐based CMC vs. aqueous‐based CMC | no estimate extracted | 1 study · 315 participants | Ungraded |
Two different concentrations of CMC + hyaluronic acid vs CMC | no estimate extracted | 1 study · 305 participants | Ungraded |
0.5% CMC vs 0.5% CMC + castor oil vs. 1.0% glycerine + castor oil | no estimate extracted | 1 study · 18 participants | Ungraded |
1.0% CMC vs. 0.18% sodium hyaluronate | no estimate extracted | 1 study · 21 participants | Ungraded |
1.0% CMC vs. 0.3% HPMC | no estimate extracted | 2 studies · 77 participants | Ungraded |
1.0% CMC vs. 0.4% carbomer | no estimate extracted | 1 study · 60 participants | Ungraded |
0.2% carbomer vs. 0.3% HPMC vs. 0.3% anhydrous liquid lanolin | no estimate extracted | 1 study · 67 participants | Ungraded |
0.2% carbomer vs. HP‐guar | no estimate extracted | 1 study · 30 participants | Ungraded |
0.3% carbomer vs. 0.18% sodium hyaluronate | no estimate extracted | 2 studies · 368 participants | Ungraded |
Carbomer gels containing different preservatives | no estimate extracted | 1 study · 179 participants | Ungraded |
0.2% PAA vs. 1.4% PVA | no estimate extracted | 2 studies · 159 participants | Ungraded |
1.4% PVA vs. 0.1% sodium hyaluronate | no estimate extracted | 1 study · 35 participants | Ungraded |
1.4% PVA vs. carbomer | no estimate extracted | 1 study · 55 participants | Ungraded |
0.3% HPMC vs. 0.4% hyaluronic acid | no estimate extracted | 1 study · 113 participants | Ungraded |
Two different products containing 0.3% HPMC | no estimate extracted | 1 study · 37 participants | Ungraded |
0.3% HPMC with vs without bicarbonate | no estimate extracted | 1 study · 27 participants | Ungraded |
0.3% HPMC vs. 1.25% castor oil | no estimate extracted | 1 study · 53 participants | Ungraded |
Trehalose + hyaluronic acid vs. PEG + PG + HP‐guar | no estimate extracted | 1 study · 17 participants | Ungraded |