Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Erythromycin vs placebo

Adverse events: minor gastrointestinal symptoms · pityriasis rosea

Erythromycin showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo (moderate certainty).

1 finding from 1 review

Azithromycin vs placebo or vitamins

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Mild abdominal pain. · pityriasis rosea

Azithromycin showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo or vitamins (moderate certainty).

1 finding from 1 review

Acyclovir vs placebo, vitamins, or no treatment

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

Acyclovir showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with placebo, vitamins, or no treatment (moderate certainty).

1 finding from 1 review

Acyclovir + calamine + cetirizine vs calamine + cetirizine

Minor participant‐reported adverse events not requiring withdrawal of the treatment: Headache. · pityriasis rosea

Acyclovir + calamine + cetirizine showed no clear difference in minor participant‐reported adverse events not requiring withdrawal… compared with calamine + cetirizine (low certainty).

1 finding from 1 review

Clarithromycin vs placebo

Minor adverse events not leading to withdrawal of treatment · pityriasis rosea

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Liver dysfunction: proportion with changed aspartate aminotransferase or alanine aminotransferase levels (> 3x ULN) ‐ at all time points · children with familial hypercholesterolemia
1 finding from 1 review

Vitrectomy vs scleral buckling

Adverse effects (cataract development, choroidal detachment, new/iatrogenic breaks, postoperative proliferative vitreoretinopathy, postoperative increase in intraocular pressure, development of cystoid macular oedema, macular pucker, strabismus) a... · people with simple rhegmatogenous retinal detachments

Pars plana vitrectomy (PPV) may leads to higher adverse effects (cataract development, choroidal detachment,… compared with scleral buckling (low certainty).

1 finding from 1 review

Staple food fortified with vitamin A plus other micronutrients vs no intervention

Subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L or less) · general population over 2 years of age

It is very uncertain whether staple food fortified with vitamin A plus other micronutrients changes subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L… compared with no intervention (very low certainty).

1 finding from 1 review

Staple foods fortified with vitamin A vs same unfortified staple foods

Subclinical vitamin A deficiency (serum/plasma retinol 70 μmol/L or less) · general population over 2 years of age

It is very uncertain whether staple foods fortified with vitamin A changes subclinical vitamin A deficiency (serum/plasma retinol 70 μmol/L or… compared with same unfortified staple foods (very low certainty).

1 finding from 1 review

Staple food fortified with vitamin A plus other micronutrients vs same unfortified staple foods

Subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L or less) · general population over 2 years of age

Staple foods fortified with vitamin A plus other micronutrients probably leads to lower subclinical vitamin A deficiency (serum/plasma retinol 0.70 μmol/L… compared with same unfortified staple foods (moderate certainty).

1 finding from 1 review

Ultrasound guidance vs no ultrasound

Minor complications (3 to 6 weeks · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

Ultrasound guidance showed no clear difference in minor complications compared with no ultrasound guidance (low certainty).

1 finding from 1 review