Dental caries · Children (<18 years) with vs without dental caries
ApaI(rs7975232) allelic model: C vs A was not significantly associated with dental caries (OR 0.89); ungraded.
1 finding from 1 review
Intervention not reported
Decayed, missing, filled surfaces (DMFS)
The intervention led to higher decayed, missing, filled surfaces (DMFS); GRADE not reported.
1 finding from 1 review
Streptococcus viridans count (CFU/mL) · Children and/or adolescents (<18 years) without background systemic disease
Only one trial (Mishra 2014) reported S. viridans count, showing a higher count with probiotics (MD 0.40 CFU/mL, 95%CI 0.33 to 0.47); not pooled or GRADE-rated.
1 finding from 1 review
Periodontal disease - novel loci (meta-analysis) · Adults from Japanese and European cohorts (present study + GLIDE + UK Biobank + BioBank Japan); periodontal disease cases vs controls
The meta-analysis found no novel loci for periodontal disease; the European SIGLEC5/chr19 locus did not replicate in Japanese populations; ungraded.
1 finding from 1 review
Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese + European cohorts) · Meta-analysis: present study + GLIDE + UKB + BBJ
Meta-analysis of periodontal disease identified only previously known loci; no novel loci. The chromosome-19 SIGLEC5 locus associated with periodontitis in Europeans was not replicated in Japanese populations (present…
4 studies · 764572 participants
GRADE not reported
Use of alternative/indigenous mouth-cleaning implements · Adult residents of slums and non-slum urban settings of LMICs
Indigenous/alternative cleaning tools and home remedies are widely used, more so in rural/slum groups; ungraded.
1 finding from 1 review
Alternative implements included toothpowder, chewing-stick, neem, charcoal, sand, snuff, salt, miswak, cotton wool and the fingers; native/indigenous tools were used more by rural and slum/disadvantaged residents than…
Studies not reported
GRADE not reported
Enamel demineralization (QLF ΔF) · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation significantly reduced enamel mineral loss versus untreated control (SMD -2.09, 95% CI -3.29 to -0.88; 4 in vitro studies; ungraded).
1 finding from 1 review
SMD -2.09 [-3.29, -0.88]
4 studies
GRADE not reported
Streptococcus mutans count · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
No difference in mean Streptococcus mutans presence was reported; GRADE was not reported.
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Caries in primary teeth: dmft (3 years) · Institutionalized orphan children (roughly 3 to 18 years)
Primary-teeth caries experience (dmf) was higher in institutionalized children than parented children but not significantly so (pooled MD 0.64; very low certainty).
1 finding from 1 review
Dental caries prevalence · Brazilian children in primary dentition (BMI classified by CDC 2000 growth charts)
Overweight may make little or no difference to the odds of dental caries in the primary dentition (very low certainty).
1 finding from 1 review
Rotation of the mandibular first premolar · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)
After mandibular first molar extraction, the first premolar was rotated in about 38% of cases (2 studies; very imprecise; not GRADE-rated).
1 finding from 1 review
Mean DFR (decayed, filled root teeth) · adults
Patients with periodontitis had a significantly higher mean DFR (WMD 1.13).
1 finding from 1 review
Spontaneous space closure · Children and adolescents with maxillary permanent first molar extraction
In the maxilla, M2 Demirjian stages A-D were not associated with a statistically significant difference in space closure odds.
1 finding from 1 review
White spot lesion formation (QLF: fluorescence loss, lesion area) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single RCT found indirect bonding with flowable composite reduced white spot lesion formation versus direct bonding (ungraded).
1 finding from 1 review
Incidence of new ICLs (proportion of subjects developing new lesions) · Patients undergoing fixed orthodontic treatment with fixed (multibracket) appliances, followed for development of new ICLs
About 48% of patients developed new ICLs during fixed orthodontic treatment (pooled incidence 0.48, 95% CI 0.33-0.63; very low certainty; very high heterogeneity).
1 finding from 1 review
Intervention not reported
Comparable diagnostic accuracy (photographic vs visual examination)
1 finding from 1 review
Prevalence of ICLs (proportion of tooth surfaces affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
About 22% of tooth surfaces showed ICLs during/after fixed orthodontic treatment (pooled 0.22, 95% CI 0.14-0.33; very low certainty; extreme heterogeneity).
1 finding from 1 review
Prevalence of ICLs (proportion of subjects affected) · Patients (permanent dentition) during or after fixed orthodontic treatment with fixed (multibracket) appliances
Around 57% of patients had ICLs during or after fixed orthodontic treatment (pooled prevalence 0.57, 95% CI 0.48-0.65; very low certainty; very high heterogeneity).
1 finding from 1 review
Periodontal conditions (gingival inflammation, bleeding on probing, probing depth, clinical attachment loss) · Children and adolescents aged 0-18 years with non-syndromic cleft lip and palate (CLP)
Narrative synthesis of 6 studies suggests children/adolescents with CLP have poorer periodontal status (higher gingival and plaque indices, deeper probing, more bleeding and attachment loss) and harbor periodontopathogens; no pooled estimate and the evidence is ungraded.
1 finding from 1 review
Crown caries · adults
Periodontitis was associated with a small increase in crown caries odds (OR 1.03).
1 finding from 1 review