Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Non‐pyrethroid‐like indoor residual spraying (IRS) plus insecticide‐treated nets (ITNs) vs ITNs alone

Anaemia prevalence · people at risk of malaria

Non‐pyrethroid‐like indoor residual spraying (IRS) plus… showed no clear difference in anaemia prevalence compared with ITNs alone (low certainty).

1 finding from 1 review

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated nets (ITNs) vs ITNs alone

Malaria parasite prevalence · people at risk of malaria

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated… showed no clear difference in malaria parasite prevalence compared with ITNs alone (moderate certainty).

1 finding from 1 review

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated nets (ITNs) vs ITNs alone

Anaemia prevalence (haemoglobin < 8 g/dL) · people at risk of malaria

Pyrethroid‐like indoor residual spraying (IRS) + insecticide‐treated… showed no clear difference in anaemia prevalence (haemoglobin < 8 g/dL) compared with ITNs alone (low certainty).

1 finding from 1 review

Intervention not reported

Malaria parasite prevalence · children and adults at risk of malaria

The intervention probably leads to lower malaria parasite prevalence (moderate certainty).

1 finding from 1 review

Intervention not reported

Anaemia prevalence · children and adults at risk of malaria

The intervention leads to lower anaemia prevalence (high certainty).

1 finding from 1 review

Intranasal steroid spray vs placebo or no intervention

Presence of normal olfactory function · people with olfactory dysfunction for less than 4 weeks following COVID‐19 infection

It is very uncertain whether intranasal steroid spray changes presence of normal olfactory function Assessed by participants as a… compared with no intervention/placebo (very low certainty).

2 findings from 1 review

Intranasal steroid drops vs placebo

Presence of normal olfactory function · participants with olfactory dysfunction following COVID‐19 for ≤ 15 days

Intranasal steroid drops showed no clear difference in presence of normal olfactory function Assessed by participants > 4… compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ LSSS intervention vs regular salt

Blood pressure target achievement · Adults (general population)

It is very uncertain whether summary of findings table ‐ LSSS intervention changes blood pressure control compared with regular salt (very low certainty).

1 finding from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Intensive periodontal treatment (subgingival SRP with or without… probably leads to lower change in diastolic blood pressure (DBP, mmHg) compared with supra-gingival scaling (moderate certainty).

3 findings from 1 review

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs No treatment (no periodontal treatment)

Diastolic blood pressure (mmHg), change from baseline · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Periodontal treatment (subgingival SRP with or without other… showed no clear difference in change in diastolic blood pressure (DBP, mmHg) compared with no treatment (no periodontal treatment) (low certainty).

2 findings from 1 review