Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,231 questions · 3,354 findings · 394 reviews

No studies found 803 · 23.9%GRADE not reported 267 · 8%Very low 757 · 22.6%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Summary of findings table ‐ Intralesional classical immunosuppresants (betamethasone or triamcinolone) vs placebo

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Intralesional classical… changes short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with placebo (very low certainty).

1 finding from 1 review

Parenteral nutrition with alanyl‐glutamine, protein, fat, carbohydrates and branched‐chain amino acids vs 5% dextrose and normal saline

1‐year‐survival · adult patients after liver transplantation.

It is very uncertain whether parenteral nutrition with alanyl‐glutamine, protein, fat,… changes 1‐year‐survival compared with 5% dextrose and normal saline (very low certainty).

1 finding from 1 review

Parenteral nutrition with alanyl‐glutamine, protein, fat, carbohydrates and branched‐chain amino acids vs 5% dextrose and normal saline

3‐year‐survival · adult patients after liver transplantation.

It is very uncertain whether parenteral nutrition with alanyl‐glutamine, protein, fat,… changes 3‐year‐survival compared with 5% dextrose and normal saline (very low certainty).

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Eating a normally varied diet · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Restoration of sexual activity · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Reduction in number of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Any topical or systemic intervention (topical/systemic steroids, ciclosporin, tacrolimus, retinoids, anti-malarials, biologics, phototherapy, surgery) vs Placebo, no treatment, another active intervention, or a different dose of the same intervention

Reduction in severity of flares · People of any age with erosive lichen planus affecting the oral, anogenital, and/or oesophageal regions

The review found no eligible studies for this question.

1 finding from 1 review

Pharmacomechanical thrombolysis (Cragg® catheter) vs pulse spray technique

Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether pharmacomechanical thrombolysis (Cragg® catheter) changes minor adverse events compared with pulse spray technique (very low certainty).

1 finding from 1 review

Surgical thrombectomy vs different types of endovascular interventions

Minor adverse events · thrombosed haemodialysis arteriovenous fistulas and grafts

It is very uncertain whether surgical thrombectomy changes minor adverse events compared with different types of endovascular interventions (very low certainty).

1 finding from 1 review

Postoperative systemic antibiotics (phenoxymethylpenicillin/penicillin VK, 7-day course), partial or total chemo-mechanical debridement and analgesics vs Matched placebo, partial or total chemo-mechanical debridement and analgesics

Number of paracetamol (acetaminophen) with codeine tablets required · Adults with a symptomatic necrotic tooth or localised acute apical abscess (no signs of spreading infection or systemic involvement)

Postoperative systemic antibiotics… showed no clear difference in number of paracetamol (acetaminophen) with codeine tablets required compared with matched placebo, partial or total chemo-mechanical debridement and…; GRADE not reported.

1 finding from 1 review