Cochrane · systematic review · CD002198
Local versus radical surgery for early rectal cancer with or without neoadjuvant or adjuvant therapy
Motamedi, MAK, Mak, NT, Brown, CJ, et al. · Cochrane Database of Systematic Reviews · 2023 · Cochrane Library
ColorectalAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 1 · 12.5%Low 5 · 62.5%Moderate 1 · 12.5%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Local excision compared to radical resection for stage I rectal cancer in adults, with or without neoadjuvant or adjuvant therapy
Population: stage I rectal cancer in adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes Local excision vs radical resection | no estimate extracted | NR | No studies |
Disease‐free survival (D‐FS)Â Local excision vs radical resection | HR 1.96 [0.91, 4.24] | 3 studies · 212 participants | Low Downgraded: risk of bias, imprecision |
Sphincter function Local excision vs radical resection | no estimate extracted | 3 studies · 165 participants | Low Downgraded: risk of bias, imprecision, indirectness |
Cancer‐related survival (C‐RS)Â Local excision vs radical resection | HR 1.42 [0.6, 3.33] | 3 studies · 207 participants | Very low Downgraded: risk of bias, imprecision |
Local recurrence‐free survival (LR‐FS)Â Local excision vs radical resection | no estimate extracted | 4 studies · 265 participants | Low Downgraded: risk of bias, imprecision |
Major postoperative complications Local excision vs radical resection | RR 0.53 [0.22, 1.28] | 4 studies · 266 participants | Low Downgraded: risk of bias, imprecision |
Minor postoperative complications Local excision vs radical resection | RR 0.48 [0.27, 0.85] | 4 studies · 266 participants | Moderate Downgraded: risk of bias, imprecision |
Quality of life Local excision vs radical resection | no estimate extracted | 1 study · 55 participants | Low Downgraded: risk of bias, imprecision, indirectness |