Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,692 questions · 2,586 findings · 180 reviews · Dental caries

No studies found 194 · 7.5%GRADE not reported 1,937 · 74.9%Very low 248 · 9.6%Low 136 · 5.3%Moderate 52 · 2%High 19 · 0.7%

Low income vs High income

Prevalence of fair/poor self-rated oral health · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

Across four countries, low versus high income differed by 15.77 percentage points in prevalence of fair/poor self-rated oral health (random-effects meta-analysis; I2=13.4%).

5 findings from 1 review
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Secondary education vs University education

Prevalence of untreated decay (% DT > 0) · Adults aged 25 years and older in Australia, Canada, New Zealand, and the United States

In United States, secondary versus university education differed by 10.4 percentage points in prevalence of untreated decay.

4 findings from 1 review
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Dementia (any type or severity) vs Older people without dementia

Denture use (prevalence) · Older people (aged 60 years or older) with dementia

Denture use was similar in older people with and without dementia, though one study reported lower denture use with more severe dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Edentulousness (prevalence) · Older people (aged 60 years or older) with dementia

Edentulousness was similar in older people with and without dementia, with wide overlapping ranges across studies; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Orofacial pain (prevalence) · Older people (aged 60 years or older) with dementia

Orofacial pain prevalence was similar in older people with dementia (7.4 to 21.7%) and without dementia (6.7 to 18.5%), based on few studies; no meta-analysis was performed (ungraded).

1 finding from 1 review

Dementia (any type or severity) vs Older people without dementia

Number of teeth · Older people (aged 60 years or older) with dementia

The number of teeth present was comparable between older people with and without dementia; no meta-analysis was performed (ungraded).

1 finding from 1 review

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Operator preference/fatigue in operator · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
  • One study (Evans 2000): 11 dental practitioners expressed a preference in 73 of 77 'dentist/patient encounters', significantly in favour of conventional drill rather than laser (P < 0.001); main difficulty with laser…
    1 study
    GRADE not reported

Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Conventional mechanical caries removal (standard drill; handpiece with a bur)

Participant preference · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
  • Three studies (Evans 2000; Liu 2006; Zhang 2013) reported participants' preference for future treatment. Zhang 2013: 37/53 children (72%) preferred laser, 10 (22%) drill. Liu 2006: 36/40 (90%) preferred laser, 4 (5%)…
    3 studies
    GRADE not reported

Breastfeeding vs Bottle feeding

Dental caries · Children with exclusively primary dentition (age ≤71 months)

In a meta-analysis of two cross-sectional studies, breastfed children had lower odds of dental caries than bottle-fed children (OR 0.43, 95% CI 0.23 to 0.80); certainty was not formally graded.

2 findings from 1 review

Down syndrome vs Individuals without Down syndrome (healthy controls: siblings, schoolchildren or others)

Dental caries · Individuals of all ages

Individuals with Down syndrome had a lower prevalence of dental caries than those without (pooled OR 0.36, 95% CI 0.22 to 0.57; 2 studies; I2=0%); certainty of evidence not graded.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Metabolic syndrome (prevalent) · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Metabolic syndrome (prevalent): OR 0.49 (95% CI 0.38 to 0.64), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Vitamin D vs placebo or control

Diastolic blood pressure · Adults (general population)

Meta-analysis of randomised trials of vitamin D supplementation for Diastolic blood pressure: WMD -0.03 (95% CI -1.98 to 1.92), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Cardiovascular disease (prevalent) · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease (prevalent): OR 0.67 (95% CI 0.55 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Depression · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Depression (Cohort studies): HR 0.44 (95% CI 0.27 to 0.72), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

2 findings from 1 review

Vitamin D vs placebo or control

Systolic blood pressure · Adults (general population)

Meta-analysis of randomised trials of vitamin D supplementation for Systolic blood pressure: WMD -2.39 (95% CI -5.7 to 0.9), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Type 2 diabetes (prevalent) · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Type 2 diabetes (prevalent): OR 0.45 (95% CI 0.25 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

DHAT-delivered dental care vs Dentist-delivered dental care

Stainless steel crown preparation and placement deficiency · Alaska dental health aide therapists

No stainless steel crown preparation deficiencies were reported; placement deficiency was 3% for DHATs versus 9% for dentists, without a GRADE rating.

1 finding from 1 review